冻干人胎盘因子对肿瘤化疗病人外周血象影响的多中心随机对照研究  

Impact of placenta factor on peripheral hemogram of patients with solid tumors treated by chemotherapy:a preliminary outcome of multicenter,randomized,and controlled study

作　　者：黄慧强[1,2] 蔡清清[1,2] 黄欣[1,2] 郭颖[1,2] 周中梅[1,2] 应江山[3] 许立功[3] 韩福才[4] 谭煌英[5] 李佩文[5] 管忠震[1,2] 

机构地区：[1]中山大学附属肿瘤医院,广东广州510060 [2]华南肿瘤学国家重点实验室 [3]复旦大学附属肿瘤医院,上海200032 [4]山西省肿瘤医院,山西太原030013 [5]中日友好医院,北京100013

出　　处：《中国新药与临床杂志》2006年第8期598-600,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的：探讨冻干人胎盘因子(PF)对肿瘤化学治疗(化疗)病人外周血象的影响。方法：共收治69例,采用自身交叉随机对照研究,即均接受2个疗程相同方案的化疗,其中一个疗程为化疗+PF (化疗+PF组),另一个疗程单用化疗(单用化疗组)。化疗+PF组d1开始用PF,隔日1次,每次18mg,im,持续3～4wk。结果：化疗后白细胞(WBC)最低点：化疗+PF组为(3．0±s 1．1)×10~9·L^(-1),单用化疗组为(2．6±1．2)×10~9·L^(-1)(P＜0．01)；WBC恢复时间：化疗+PF组和单用化疗组分别为(5±4)d和(11±20)d(P=0．005)。未发现不良反应。结论：PF可改善化疗所引起的骨髓抑制,有助提高化疗的耐受性。AIM： To evaluate the impact of lyophilized human placenta factor （PF） on the peripheral hemogram of patients treated with chemotherapy. METHODS： Sixty-nine patients were eligible for a self-cross,randomized, and controlled study. All patients received 2 cycles of chemotherapy, including one cycle of chemotherapy plus PF （therapy group）, and another cycle of chemotherapy alone （control group） . PF was administered intramuscularly at a dose of 18 mg per person every other day from the beginning of chemotherapy for three to four weeks. RESULTS： The nadirs of WBC were （3.0±s 1.1）×10^9·L^-1 in therapy group and （2.6±1.2）×10^9·L^-1 in control group, respectively （P 〈 0.01） . The median recovery times of WBC in therapy group and control group were （5 ±4） d and （11±20） d, respectively （P = 0.005） . No adverse effect of PF was occured. CONCLUSION： PF can reduce the severity of myelosuppression induced by chemotherapy and improve the tolerance of chemotherapy.

关 键 词：肿瘤 药物疗法 白细胞 多中心研究 随机对照试验 药物不良反应 胎盘因子 

分 类 号：R973.4[医药卫生—药品] R979.1[医药卫生—药学]