碳酸化羟基磷灰石/胶原(nCHAC)生物复合材料的室温制备及表征  

The Preparation and Characterization of a Carbonated Hydroxyapatite/Collagen Composite at the Room Temperature

作　　者：徐国富[1] 牟申周[1] 廖素三[2] Fumio Watari 

机构地区：[1]中南大学材料科学与工程学院,长沙410083 [2]北海道大学,日本札幌0608586

出　　处：《材料导报》2006年第8期140-142,148,共4页Materials Reports

基　　金：日本学术振兴会(JSPS)科研基金资助课题(编号:20030254)

摘　　要：通过仿生自组装法在室温下制备了纳米碳酸化羟基磷灰石/胶原(nCHAC)复合材料,并借助X射线衍射(XRD)分析、热分析(TGA)和透射电镜(TEM)的观察对其进行了表征,结果表明:(1)该材料具有与天然骨相同的纳米尺度和胶原蛋白无机相,含有2.8%～14.7%(wt)的碳酸成分;(2)显微结构是矿化的胶原纤维束,类似于天然骨的分级结构。揭示了碳酸和胶原含量不同的复合材料中具有微小差别的自组装单元。碳酸的百分含量影响矿物的晶体尺寸和胶原纤维的组装。因此,nCHAC复合材料是有前途的硬组织修复用材料,这要归功于生物仿生制备出的材料具有与天然骨类似的成分和类似的微观结构。Nano-carbonated hydroxyapatite/collagen （nCHAC） composite is prepared at room temperature via biomimetic self-assembly method. It＇s characterized by X-ray diffraction （XRD）, thermogravimetric analysis （TGA）, and transmission electron microscopy （TEM）. This composite shows the same inorganic phase of natural bone with nano-sized level and low crystallinity degree, and contains 2. 8%～14. 7% （wt） of carbonated content. TEM results confirm that the microstructure of this composite is the mineralized collagen fiber bundle like the hierarchical structure of natural bone. The diameter of single mineralized collagen fiber is about 4nm. Moreover, the little different assembly units of the composite with different carbonated and collagen are demonstrated. The carbonated percentage affects the mineral crystal size and collagen fibril assembly. Due to the biomimetic component and microstructure, the nCHAC composite is promising for hard tissue therapy.

关 键 词：碳酸化羟基磷灰石 仿生 胶原矿化 

分 类 号：R318.08[医药卫生—生物医学工程]