糖基化终末产物与冠心病相关性的临床观察  

Clinical observations on correlation between advanced glycation end products and coronary heart disease

作　　者：杨胜荣[1] 朱玉霞[1] 李炀[1] 张艳秋[1] 

机构地区：[1]天津公安医院内三科,天津300050

出　　处：《中国心血管杂志》2006年第4期255-256,265,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：目的探讨糖基化终末产物与冠心病的相关性。方法分别检测正常对照组、冠心病组、糖尿病组及冠心病合并糖尿病组的血清糖基化终末产物、糖化血红蛋白,并进行相关分析。结果各观察组血清糖基化终末产物均较正常对照组升高,且各组间的差异有显著性(P<0.05),糖基化终末产物与糖化血红蛋白呈正相关(r=0.738,P=0.000)。结论血清糖基化终末产物与冠心病具有相关性,并且是糖尿病心血管合并症的相关危险因素。Objective To explore the relationship between AGE and CHD. Methods AGE and HbAlc were tested in each group, including control, CHD, DM, both CHD and DM group. Correlative analysis was carried out. Results AGE were significantly higher in each observational group compared to that in control group（ P 〈 0.05）. AGE was significantly positively correlated with HbAlc（ r = 0. 738, P = 0. 000）. Conclusions AGE was correlated with CHD, it＇s a risk factor related to diabetic cardiovascular disease.

关 键 词：糖基化终末产物 冠心病 2型糖尿病 相关性分析 

分 类 号：R541.4[医药卫生—心血管疾病] R589.1[医药卫生—内科学]