卡孕栓预防阴道分娩产后出血的给药方式探讨  

Administration Route of Mehyl Carprost Suppository in Reducing the Postpartum Hemorrhage

作　　者：谭淑卓[1] 陈春宁[1] 

机构地区：[1]河北医科大学第二医院妇产科,河北省石家庄市050000

出　　处：《中国全科医学》2006年第16期1361-1362,共2页Chinese General Practice

摘　　要：目的探讨卡孕栓(Carprost)用于阴道分娩产后出血的最佳给药方式。方法200例产妇随机分为两组,卡孕栓直肠给药组(A组,100例)产妇在胎儿娩出后即刻将卡孕栓1mg置于直肠内;卡孕栓舌下含服组(B组,100例)产妇在胎儿娩出后即刻舌下含服卡孕栓1mg,A、B两组产妇均同时宫体注射催产素20U,观察两组产妇产后2h、24h的出血量及分娩后的宫底高度。结果(1)两组产妇产后2h、24h的平均出血量间差别均有显著性意义(P<0·05);(2)两组产妇分娩前及分娩后24h宫底高度间差别均无显著性意义(P>0·05),而分娩后0·5h、1h、2h的宫底高度间差别均有显著性意义(P<0·05);(3)两组产妇用药前、后血压均值间差别均无显著性意义(P>0·05)。(4)A组有2例患者出现恶心,B组有1例患者出现寒战,1例出现面部热感。结论阴道分娩产妇卡孕栓直肠给药较舌下含服更有效。Objective To investigate the administration route of Mehyl Carprost Suppository in reducing the postpartum hemorrhage. Methods 200 lying - in women were randomly divided into group A （ 100 women with administering Mehyl Carprost Suppository lmg via the rectum ） and group B （100 women with taking the medicine ling sublingually）. Pitoein 20 U was used by uterus body injection in two groups after childbirth. To measure the hemorrhage quantity within 2 hours and 24 hours after delivery in group A and B. Results In group A, the average hemorrhage quantity within 2 hours and 24 hours after delivery was 150. 3ml and 265.4ml respectively. In group B, it was 170. 6ml and 295.5ml respectively. Significant difference was observed in two groups （ P 〈0. 05）. 4 of 200 women were found having side effect, which alleviated by themselves 35 minutes later. Conclusion Rectum administration of Mehyl Canprost Suppository was more effective than the sublingual administration for vaginal delivery women.

关 键 词：卡孕栓 阴道分娩 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]