超临界CO_2萃取工艺对蛇床子提取物提取率的影响  

Influence of the technology of supercritical CO_2 extraction on the separate rate of the extractives from fruits of Cnidium Monnieri(L.) Cuss.

作　　者：宫竹云[1] 张高勇[1] 聂永亮[1] 谷惠先[1] 

机构地区：[1]中国日用化学工业研究院,山西太原030001

出　　处：《中成药》2006年第8期1102-1107,共6页Chinese Traditional Patent Medicine

基　　金：山西省高级专家项目(No.204512)

摘　　要：目的:采用二次回归连贯设计来确定超临界CO2萃取蛇床子提取物的工艺参数。方法:萃取压力和温度,分离压力和分离温度(Ⅰ和Ⅱ)作为因素。结果:优化的工艺条件为:萃取压力为20 MPa,萃取温度40°C;分离Ⅰ压力为15 MPa,分离Ⅰ温度为65°C;分离Ⅱ压力为5 MPa,分离Ⅱ温度为38°C;CO2流量为18 L/H,萃取时间为80 m in。结论:在此条件下,蛇床子提取物的提取率可达24.03%。采用二次回归连贯设计可以客观地反应各因素对目标函数的影响规律。AIM： To use secondary regression coherent design to explore the extraction parameters of fruits of Cnidiunm by supercfitical CO2 extraction. METHODS： Extraction pressure, extraction temperature, isolation pressure, isolation temperature I and Ⅱ were viewed as factors. RESULTS： The best technological conditions were： extractive kettle pressure was 20 MPa, extractive kettle temperature was at 40 ℃ ; separate kettle I pressure was 15 MPa, separate kettle I temperature was at 65 ℃; separate kettle Ⅱ pressure was 5 MPa, separate ketle Ⅱ temperature was at 38 ℃; CO2 flow rate was 18 L/H,extractive time was 80 min. CONCLUSION： Under these conditions, the separate rate of the extractives from fruits of Cnidium Monnieri（ L. ） Cuss. could be 24.03%. Using secondary regression coherent design could naturally react the influence of the rule on the every factor to the goal function.

关 键 词：超临界 蛇床子提取物 提取率 二次回归连贯设计 

分 类 号：R284.1[医药卫生—中药学]