五味子配方颗粒工艺研究  

Processing parameter of Fructus Schisandrae Chinensis dispensing granules

作　　者：李霞[1] 贾晓斌[1] 陈彦[1] 范晨怡[1] 黄丽霞[2] 魏惠华[2] 

机构地区：[1]江苏省中医药研究院江苏省现代中药制剂工程技术研究中心 [2]苏州雷允上药业有限公司,江苏苏州215003

出　　处：《中成药》2006年第8期1122-1126,共5页Chinese Traditional Patent Medicine

基　　金：江苏省135工程重点人才资助项目(65RC2002065)

摘　　要：目的:优化五味子配方颗粒的制剂工艺。方法:以五味子醇甲、五味子酯甲、五味子甲素、五味子乙素为指标,考察提取溶媒、药材破碎程度对提取工艺的影响,并优选提取工艺参数。结果:五味子药材破碎后以乙醇提取,其活性成分可得到有效提取,优化后提取工艺参数为药材破碎过40目筛,以70%乙醇提取2次,每次提取2 h。结论:五味子配方颗粒工艺经过优化,比目前市售产品工艺合理,质量得到保证。AIM： To optimize the preparation process of Fructus Schisandrae Chinensis dispensing granules METHODS ： Schizandrin, schisantherin A, deoxyschizandrin, r-schizandrin were viewed as the indexes of judgement criteria, the influencing factors of extraction process as extract solvent, medical material particle diameter were stud- ied and extraction parameters were optimized. RESULTS： Active components of dispensig granules can be extracted effectively by alcohol when medical materials were crushed. The best conditions were as follows：medical material were ground into 40 mesh,extracted two times by 70% alcohol,2 h per time. CONCLUSION： After being optimized, The process of dispensing granules is better than that of products on market.

关 键 词：五味子 配方颗粒 工艺 五味子醇甲 五味子酯甲 五味子甲素 五味子乙素 

分 类 号：R927.2[医药卫生—药学]