小剂量抗抑郁药治疗难治性结肠易激综合征的疗效观察  

Effect of Subclincal Dosage of Antidepressants on Refractory Irritable Bowel Syndrome

作　　者：刘德良[1] 霍继荣[1] 吴小平[1] 卢放根[1] 周恩相[1] 

机构地区：[1]中南大学湘雅二医院消化科,湖南长沙410011

出　　处：《中国临床心理学杂志》2006年第4期424-425,共2页Chinese Journal of Clinical Psychology

摘　　要：目的:探讨小剂量抗抑郁药治疗难治性结肠易激综合征的疗效。方法:采用自身对照研究,选择符合罗马Ⅱ诊断标准的难治性非便秘型肠易激综合征患者46例,给予小剂量氟西汀或帕罗西汀(10mg/d),疗程12周;采用症状严重度与频率指数、汉密尔例顿抑郁量表(HAMD)及汉密顿焦虑量表(HAMA)评分对其疗效进行评价。结果:46名患者均完成了抗抑郁药治疗,疗程结束后患者症状严重度与频率指数较治疗前均显著降低(P<0.01),HAMD、HAMA评分亦明显下降(P<0.01)。结论:小剂量抗抑郁药是治疗难治性结肠易激综合征的安全和有效的药物。Objective： To itvestigate the effect of Antidepressant on refractory irritable bowel syndrome（IBS）. Methods： A self-control study of subclincal dosage of antidepressants therapy（fluoxetine 10mg/d or paroxetine 10mg/d） for 12 weeks in 46 patients with refractory IBS was performed. The clinical outcomes were evaluated by indexs of symptom severity and symptom frequency and the score of Hamiton depession scale （HAMD） and Hamiton anxiety （HAMA）. Results： All 46 cases completed the therapy. After the course of treatment, indexes of symptom severity and symptom frequency and the scores of HAMD and HAMA were significantly lower than those before treatment （P〈0.01）. Conclusion： Subclincal dosage of antidepressant is an effective and safe drug for treatment of refractory IBS.

关 键 词：肠易激综合征 抗抑郁药 治疗 

分 类 号：R395.5[哲学宗教—心理学]