前稀释高容量联机血液滤过与低通量血液透析清除效果的前瞻性交叉研究  

Pre-dilution high volume on-line hemofiltration versus low permeable hemodialysis:a prospective cross-over study

作　　者：周红卫[1] 谢恺庆[1] 廖松[1] 伍民生[1] 覃香芬[1] 

机构地区：[1]广西医科大学第一附属医院血液净化中心,南宁市530021

出　　处：《实用医学杂志》2006年第17期1985-1987,共3页The Journal of Practical Medicine

摘　　要：目的:比较前稀释高容量联机血液滤过(HF)与低通量血液透析(HD)清除的效果。方法:对10例维持性HD患者采用前瞻性、随机、交叉研究,观察两种血液净化治疗前后血清肌酐(Scr)、血尿素氮(BUN)、血磷、β2微球蛋白(β2-MG)、瘦素(leptin)水平变化及评价尿素清除指数。结果:HF组β2-MG、瘦素下降率明显高于HD组(P<0.01),而BUN、Scr下降率及一室尿素清除指数、二室尿素清除指数低于HD组(P<0.05)。两组血磷下降率差异无显著性。结论:前稀释高容量联机HF清除较大分子量尿毒症毒素明显优于低通量HD。Objective To compare the clearance effect of pre-dilution high volume on-line hereofiltration （HF）with that of low permeable hemodialysis（HD） . Methods 10 uremic patients were included in this prospective cross-over study. They were randomly administered with either pre-dilution high volume on-line hemofiltration or low permeable hemodialysis and their serum levels of creatinine, blood urea nitrogen, phosphate, β2-microglobulin, and leptin were observed before and after the two different procedures. Kt/V was evaluated. Results Compared with those in the patients undergoing HD, serum β2-microglobulin and leptin in the patients undergoing HF were significantly decreased（ P 〈 0.01 ）, whereas serum blood urea nitrogen, creatinine, KT/Vsp and KT/Vdp were lower（ P 〈 0. 05）. There was no significant difference in serum phosphate between the patients undergoing HF and HD. Conclusion Pre-dilution high volume on-line bemofiltration are markedly superior to low permeable hemodialysis in the clearance of larger uremic toxin molecules.

关 键 词：血液滤过 肾透析 交叉研究 

分 类 号：R692.5[医药卫生—泌尿科学]