痛风急性发作期中医辨证分型与血流变及血小板活化功能关系的研究  

Research in relationship among TCM syndrome differentiation,hemorrheological and platelet activating factor in the podagra arthritis of acute of episode

作　　者：邵沛[1] 黄星涛[1] 张帆[1] 谢谦[1] 聂李平[1] 张涛[1] 

机构地区：[1]北京大学深圳医院广东,深圳518036

出　　处：《广州医药》2006年第5期65-68,共4页Guangzhou Medical Journal

基　　金：广东省中医药管理局课题(2050050);教育部留学回国人员启动基金资助项目(2005383)

摘　　要：目的探讨痛风急性发作期患者的中医辨证分型与血液流变学、血小板活化功能的关系。方法选择痛风急性发作期患者40例,健康体检者20例为对照组,以辨证分型、血液流变学、血小板活化功能PAC-1,CD62p检测为指标。结果痛风急性期患者湿热痹阻,瘀热内郁组血流变表现为全血粘度(低切、中切、高切)、血浆粘度、红细胞电泳与聚集指数均显著高于正常对照组(P<0.01)。两组血小板活化功能PAC-1,CD62p,均显著高于对照组(P<0.01)。而瘀热内郁组对比湿热痹阻组血小板活化功能PAC-1,CD62p,显著升高(P<0.01)。结论说明痛风急性发作期中医辨证分型与血流变及血小板活化功能之间存在着相关性,湿热痹阻、瘀热内郁是痛风急性期的基本征候和原发病机,两组间指标水平的差异可能是痛风出现不同证型的内在因素之一。Objective to observe relationship among TCM syndrome differentiation, hemorrheological and platelet activating factor in the podagra arthritis of acute of episode. Methods 40patients of podagra arthritis were divided into 2 groups named Shire-Bizu and Yure-Neiyu. with TCM syndrome differentiation. To test the patient weth hemorrheological and platelet activating factor PAC-1, CD62p The 20 healthy with the same test as the controlled groud. Results Plasma viscosity, whole blood viscosity; erythroeyte eleetrophoresis, erythroeyte aggregation index and platelet activating factor PAC-1, CD62p in podagra arthritis group were more significant increased than controlled group. And the platelet activating factor PAC-1, CD62p in Yure-Neiyu group was more significant increased than Shire-Bizu group. Conclusion TCM syndrome differentiation is likely to have relationship with bemorrbeological and platelet activating factor in the podagra arthritis of acute of episode. It could be used as a index to judge the state of an illness and prognosis.

关 键 词：痛风性关节炎 血液流变学 血小板活化功能 辨证分型 

分 类 号：R259[医药卫生—中西医结合]