XPD基因多态性与慢性苯中毒遗传易感性的相关性  

Association between polymorphisms of XPD gene and susceptibility to chronic benzene poisoning

作　　者：黄慧隆[1] 许建宁[1] 王全凯[1] 王雅文[1] 杨敏[1] 陈艳[1] 李桂兰[1] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所毒理学研究室,北京100050

出　　处：《中华劳动卫生职业病杂志》2006年第7期390-393,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金(30300279)

摘　　要：目的探讨着色性干皮病基因D(XPD)基因多态性与慢性苯中毒遗传易感性的关系。方法采用病例-对照研究方法,以确诊并已脱离苯作业的80名慢性苯中毒患者为病例组,以同期接苯的62名苯作业工人为对照组,应用PCR-RFLP分析技术,检测XPD基因密码子156、312和751位点的多态性。结果校正性别、工龄、吸烟和饮酒等因素后,携带XPD 751Gln变异等位基因的个体发生慢性苯中毒的危险性升高,OR_(adj)为2．903,95%CI：1．054～7．959,差异有统计学意义(P＜0．05)。结论在相同苯作业暴露环境下,携带XPD 751Gln变异等位基因个体发生慢性苯中毒的危险性升高。Objective To explore the relationship between genetic polymorphisms of XPD gene and susceptibility to chronic benzene poisoning. Methods A case control study was conducted. Eighty patients diagnosed with chronic benzene poisoning and 62 workers occupationally exposed to benzene who were engaged in the same woking time and job title as patients were investigated. PCR-RFLP was used for detecting the single nucleotide polymorphisms（SNPs） on cedon156,cedon312and cedon751 of XPD gene. Results There was a 2.903 times（95% CI：1. 054 - 7. 959, P = 0. 039 2） increased risk of chronic benzene poisoning in the subjects carrying XPD 751Gln variant allele compared with those carrying XPD 751Lys/Lys genotype, after adjusted for sex, length of service,smoking and drinking status. Conclusion The subjects with XPD 751Gln variant allele are more susceptive to benzene.

关 键 词：着色性干皮病基因D 慢性苯中毒 基因多态性 遗传易感性 

分 类 号：R135.12[医药卫生—劳动卫生]