中药贝母中水溶性成分的研究  

Studles on the Water Soluble Constituentsof Chinese Drug Beimu , the Bulbs of Fritillaria Plants

作　　者：陈泽乃[1] 陆阳[1] 徐佩娟[1] 高用明 邓克敏[1] 陈聪颖[1] 

机构地区：[1]上海第二医科大学化学教研室

出　　处：《中国中药杂志》1996年第7期420-422,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：根据４种贝母抑制由ＰＡＦ诱导血小板聚集部位筛选结果，从平贝母的水溶性活性部位中分得胸苷和腺苷等成分。试验表明腺苷为抑制聚集的主要成分。提示核苷类可能是贝母中除生物碱外的另一类活性成分。Based on platelet aggregation induced by platelet activating factor(PAF) .the active fraction with in-hibiting effect was sereened from four spacies of Chinese drung Beimu.the bulbs of Fritillaria przewalskii, F. us-suriensis. F. anhuiensis and F. thunbergii.According to the experimental results. the active water soluble fraction ofF. ussuriensis was further studied. Two nucleosides, thymidine and adenosine were isolated. Platelet aggregation as-say shows that adenosine is the chief aggregation inhibitor with 1%= 42 at 5μm. It is suggestad that nucleosides maybe the other type of active constituent besides alkaloids in the Fritiaria plants.

关 键 词：中药 贝母属 平贝母 腺苷 胸苷 成分分析 

分 类 号：R284.1[医药卫生—中药学]