愈心痛胶囊治疗不稳定性心绞痛临床研究  

Clinical Study on Effect of Yuxintong Capsule in Treating Unstable Angina

作　　者：雷燕[1] 陈可冀[1] 柯元南[1] 葛崇华 陈朋明 徐亚萍 

机构地区：[1]中国中医研究院西苑医院,中日友好医院心内科,中日友好医院临床研究所

出　　处：《中国中西医结合杂志》1996年第10期580-584,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：本研究观察了益气活血方药愈心痛胶囊配合常规西药治疗３４例不稳定性心绞痛（ＵＡ）的临床疗效。结果显示：（１）愈心痛组在总的临床疗效方面和在心电图缺血性ＳＴ段恢复、心绞痛分级改善、硝酸甘油消耗量减少以及平均起效时间上均明显优于西药对照组（总有效率分别为９４．１％和７４．２％，Ｐ＜０．０５）；同时，患者的自觉症状和血瘀征象也明显好转。（２）实验室检测表明，ＵＡ患者较正常对照组，外周血循环内皮细胞（ＣＥＣ）数量及血浆内皮素（ＥＴ）、丙二醛（ＭＤＡ）和α－颗粒膜蛋白（ＧＭＰ－１４０）浓度显著增高，而红细胞超氧化物歧化酶（ＳＯＤ）和全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性显著降低，提示ＵＡ患者存在严重的内皮功能损伤，体内血小板活化程度较高及抗脂质过氧化能力下降。给予愈心痛治疗２周后，血中ＣＥＣ数量及ＥＴ、ＭＤＡ和ＧＭＰ－１４０含量均显著降低，而ＳＯＤ、ＧＳＨ－Ｐｘ活性显著升高（Ｐ＜０．０１～０，００１），疗效明显优于西药对照组（Ｐ＜０．０５～０．０１）。提示愈心痛胶囊与抗心绞痛西药有协同治疗作用，可能是通过改善血管内皮功能，拮抗ＥＴ，抑制血小板活化和减轻脂质过氧化损伤等途径来达到治疗ＵＡ的目的。The Yuxintong (YXT) capsule, which possesses effects of removing blood stasis and replenishing Qi, was used to treat patients with unstable angina (UA).Sixty-five patients were divided randomly into YXT group (34 cases) and control groups (31 cases). Conventional Western medicine therapy was given to both groups and YXT was given to YXT group in addition. Results showed that: (1)Effect of YXT group was superior to that of control group in general clinical efficacy,recovery of ischemic S-T segment changes in electrocardiogram, improvement of grading of angina,reduction in consumption of nitroglycerine, and mean onset time of effect. Meanwhile, the subjective symptoms and signs of blood stasis also improved evidently. (2)Laboratory findings displayed obvious elevation of peripheral circulatory endothelial cells, plasma endothelin (ET), malonyldialdehyde and α-granule membrane protein-140, as well as markedly reduction of erythrocyte superoxide dismutase and glutathione peroxidase activity,P<0 . 01～0. 001. The effect of YXT group was significantly better than that of control group,P< 0. 05～0 .01. These findings suggested that YXT could supplemented Western medicine of antiangina, it might act by means of improving the function of vascular endothelia, antagonising against ET, inhibiting the platelet activation and reducing the damage induced by lipid peroxidation.

关 键 词：不稳定性 心绞痛 愈心痛胶囊 

分 类 号：R259.414[医药卫生—中西医结合] R286.23[医药卫生—中医内科学]