肝血虚证患者红细胞膜ATP酶活性和红细胞耗氧率变化  

Assay of Adenosine Triphosphatase Activity and Oxygen Consumption Rate of Erythrocyte Membrane in Patients with Liver-Blood Deficiency Syndrome

作　　者：石林阶[1] 刘俊凡[1] 张自强 卢义钦[1] 舒毅刚[1] 陈国林[1] 邢之华[1] 徐金耀 

机构地区：[1]湖南医科大学中西医结合研究所,湖南医科大学生化教研室和血液生化研究室,湖南医科大学湘雅医院血液病研究室

出　　处：《中国中西医结合杂志》1996年第10期593-595,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金

摘　　要：对辨证属肝血虚证的缺铁性贫血和慢性再生障碍性贫血患者分别进行红细胞膜ＡＴＰ酶活性及耗氧率的检测。结果表明，肝血虚证患者红细胞膜Ｍｇ^（２＋）－ＡＴＰ酶、Ｎａ~＋－Ｋ~＋－ＡＴＰ酶及Ｃａ^（２＋）－ＡＴＰ酶活性均显著低于健康对照组（Ｐ均＜０．０１），红细胞耗氧率亦较健康对照组降低（Ｐ＜０．０１）。提示肝血虚证患者红细胞膜ＡＴＰ酶活性与红细胞耗氧率低下，以致能量代谢减退。The adenosine triphosphatase (ATPase) activity and oxygen consumption rate (OCR) of erythrocyte membrane were determined in patients of iron-deficiency anemia or chronic aplastic anemia with Liver-Blood Deficiency Syndrome (LBDS) diagnosed by Differentiation of TCM. Results showed that the ATPase activity of patients (Mg￣(2+)-ATPase, Na￣(+)-K￣(+)-ATPase and Ca￣(2+)-ATPase) lowered very significantly, P < 0 . 01, and OCR also decreased significantly, P < 0 . 05, as compared with normal control. It suggested that both the ATPase activity and OCR of erythrocyte membrane were reduced in LBDS patients, thus to cause the energy hypometabolism.

关 键 词：肝血虚证 红细胞膜 缺铁性贫血 中医药疗法 

分 类 号：R259.563[医药卫生—中西医结合]