汉防己甲素对阿霉素或长春新碱耐药株人癌细胞的逆转抗药性作用  

Reversal of Adriamycin or Vincristine Resistance by Tetrandrine in Human Cancer Cells in Vitro

作　　者：叶祖光[1] 孙爱续[1] 李兰芳[1] 曹秀芳[1] 叶文华[1] 

机构地区：[1]中国中医研究院中药研究所

出　　处：《中国中药杂志》1996年第6期369-371,共3页China Journal of Chinese Materia Medica

摘　　要：在敏感株和阿霉素耐药株ＭＣＦ－７和ＭＣＦ－７／Ａｄ以及敏感株和长春新碱耐药株ＫＢ和ＫＢｖ２００两种人癌细胞的体外试验中，发现汉防己甲素对耐药细胞株的ＭＣＦ－７／Ａｄ具有明显的选择性作用。In an in vitro culture system of human cancer cells MCF 7 and its adriamycin resistant line MCF 7/Ad or KB and its vincristine resistant line KBv 200 ,tetrandrine was found to exhibit significantly selective anticancer activity against the drug resistant cancer cell MCF 7/Ad.In addition,essentially complete reversal effects of tetrandrine on drug resistance were observed in MCF/Ad or KBv 200 .

关 键 词：汉防己甲素 阿霉素 长春新碱 肿瘤 抗药性 

分 类 号：R979.1[医药卫生—药品] R730.5[医药卫生—药学]