ATP-MgCl_2对烫伤大鼠肠粘膜保护作用的实验观察  

Protective effect of ATP-MgCl_2 on gut mucosa in burn rat.

作　　者：苏映军[1] 陈璧[1] 汤朝武[1] 贾赤宇[1] 

机构地区：[1]第四军医大学西京医院烧伤科,西安710032

出　　处：《中华整形烧伤外科杂志》1996年第3期171-173,共3页

摘　　要：为研究 ATP-MgCl_2对创伤应激动物肠粘膜的保护作用,采用30%TBSAⅢ度烫伤大鼠模型,观察了腹腔注射 ATP-MgCl_2复合液对回肠粘膜丙二醛(MDA)含量及回肠组织形态学改变的影响。结果显示:烫伤后6～24小时,MDA 含量明显升高,并伴有形态学病理改变。经 ATP-MgCl_2注射治疗的大鼠伤后24小时内 MDA 含量维持于正常对照水平,且回肠粘膜病理改变减轻。提示:ATP-MgCl_2能够保护烫伤大鼠肠粘膜,其作用机理可能与降低肠粘膜的脂质过氧化反应有关。In order to study the protective effect of ATP-MgCl_2 on gut mucosal barrier function in trauma-induced stressed animal,full thickness burn of 30% total body surface area (TBSA) was pro- duced in rats,and ATP-MgCl_2 was injected intraperitoneally right after scald-injury.Malondialdehyde (MDA) contents of ileum mucosa were determined and morphological alteration in the ileum was ob- served under light microscope.The results showed that ileum mucosal MDA content increased signifi- cantly,accompanied by obvious morphological change,after the injury,whereas MDA content was main- tained at the normal control level and pathological alteration in ileum tissue was abated after the use of ATP-MgCl_2.It suggests that ATP-MgCl_2 possesses a protective effect on gut mucosal barrier function of scald-injured rat,and the mechanism involved may be related to the inhibition of lipid peroxidation in gut mucosa.

关 键 词：ATP-MGCL2 烧伤 丙二醛 肠粘膜 

分 类 号：R644[医药卫生—外科学]