液相色谱手性拆分机理的热力学方法研究  

Thermodynamic Studies on Mechanism of Chiral Resolution by Liquid Chromatography

作　　者：翁文[1] 姚碧霞[1] 陈秀琴[1] 陈友遵[1] 林文士[1] 曾庆乐[2] 

机构地区：[1]漳州师范学院化学与环境科学系,漳州363000 [2]厦门大学化学系,厦门361005

出　　处：《化学进展》2006年第7期1056-1064,共9页Progress in Chemistry

基　　金：福建省自然科学基金(No.C0540024);福建省教育厅课题(No.JA05301)资助

摘　　要：手性识别是分子识别的一个重要组成部分。液相色谱手性拆分机理研究有助于色谱条件的优化和新型手性固定相的设计,也有助于理解手性识别机制。本文就线性色谱与非线性色谱条件下手性拆分过程对应热力学参数的推求方法进行了评述,阐述了相关热力学参数的涵义及其在色谱保留及手性拆分机理探讨中的应用,并展望了该领域的研究前景。Chiral recognition is an important part of molecular recognition. Studies of mechanistic aspects of chiral resolution by liquid chromatography are helpful to optimize chromatographic conditions, to design novel chiral stationary phases and to understand ehiral recogniton mechanisms. In this paper, the methodologies for deriving corresponding thermodynamic parameters in the chiral resolution processes by linear or nonlinear chromatography are reviewed. The meaning of correlative parameters is explained. The applications of these parameters in the studies of mechanistic aspects of retentions and ehiral resolutions by liquid chromatography are expatiated, and corresponding research prospects are put forward.

关 键 词：液相色谱 手性拆分 手性识别 热力学参数 

分 类 号：O657.7[理学—分析化学] O642.4[理学—化学]