复方黄芪治疗慢性乙型肝炎的临床及实验研究  

Clinical and Experimental Studies on Effects of Chronic Hepatitis B Treated with Astragali Composita

作　　者：刘克洲[1] 徐陈槐[1] 章明太[1] 陈智[1] 顾亚仙[1] 蔡培仁 何南祥[1] 金建华[1] 徐辉 华炯钢 陈明华[1] 陈宝珠 

机构地区：[1]浙江医科大学传染病研究所,浙江省农业科学院病毒室,浙江医科大学第一附属医院中医科

出　　处：《中国中西医结合杂志》1996年第7期394-397,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：浙江省中医管理局;浙江省教委资助

摘　　要：用复方黄芪治疗慢性迁延性肝炎８７例和慢性活动性肝炎２９例，临床显效率分别为６９．０％和５５．２％，总有效率分别为９０．８％和８９．７％；血清ＨＢｅＡｇ和ＨＢＶ－ＤＮＡ阴转率分别为２７．７％和２８．０％，均显著高于对照组（Ｐ＜０．０５～０．０１）。治疗鸭乙型肝炎模型８只，血清ＤＨＢＶ－ＤＮＡ阴转３只，ＤＨＢＶ－ＤＮＡ平均水平治后比治前明显下降（Ｐ＜０．０５）；鸭肝组织呈轻度炎症改变者３只，病变比对照组轻，原位杂交ＤＨＢＶ－ＤＮＡ定位２只鸭阴性。结果显示，复方黄芪具有较好保肝和一定的抑制ＨＢＶ复制作用。Eighty-seven cases of chronic persistent hepatitis(CPH) and 29 cases of chronic active hepatitis(CAH) were treated with Astragali Composita(AC),the clinical markedly effective rates were 69.0% and 55.2%,the total effective rates were 90.8% and 89.7% respectively,the sero-negative conversion rates of HBeAg and HBV-DNA were 27.7% and 28.0% respectively,they were higher than that of control group(P<0.05￣0.01).Eight ducks infected duck hepatitis B virus were treated with AC,sero-negative conversion of DHBV-DNA was seen in 3 ducks,DHBV-DNA levels of duck sera were lower after treatment than that before treatment(P<0.05);mild inflammatory changes in liver tissues were seen in 3 ducks,its pathologic changes were milder than that of control groups;DHBV-DNA in liver tissues of 2 ducks was negative in situhybridization.The results indicated that AC had obvious effects of protecting liver tissues and some effects of inhibiting sera HBV and HBV replication.

关 键 词：复方黄芪 慢性 乙型肝炎 中医药疗法 

分 类 号：R259.126.2[医药卫生—中西医结合]