支气管肺灌洗液中SOD和LPO与肺气虚证的关系  

Relationship between Lipid Peroxidase and Superoxide Dismutase in Bronchoalveolar Lavage Fluid and Pulmonary Qi Deficiency Syndrome

作　　者：赵江云[1] 宋卫东[1] 刘中本[1] 吴华强[1] 张安成[1] 庞玉英[1] 刘丽华[1] 

机构地区：[1]安徽中医学院中医药研究所,安徽医科大学

出　　处：《中国中西医结合杂志》1996年第7期405-407,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金;国家中医药管理局资助

摘　　要：检测４０例慢性支气管炎肺气虚证患者及３６名健康人外周血、支气管肺灌洗液（ＢＡＬＦ）中超氧化物歧化酶（ＳＯＤ）、过氧化脂质（ＬＰＯ）以及肺泡巨噬细胞（ＡＭ）内ＳＯＤ含量。结果表明：（１）肺气虚证患者外周血ＳＯＤ、ＬＰＯ与健康对照组无明显差异。（２）肺气虚证患者ＢＡＬＦ中ＬＰＯ明显升高，而ＳＯＤ明显下降。（３）相关分析发现，ＢＡＬＦ中ＳＯＤ主要与ＡＭ数量相关，而ＬＰＯ主要与中性粒细胞数量相关。ＢＡＬＦ中ＳＯＤ和ＬＰＯ是评价肺气虚证的指标之一。Investigating the levels of lipid peroxidase(LPO) and superoxide dismutase(SOD) in serum,bronchoalveolar lavage fluid(BALF) and alveolar macrophage(AM) were determined in 40 chronic bronchitis patients with Pulmonary Qi Deficiency(PQD) Syndrome and 36 normal subjects.Results showed:(1) No significant differences were found between PQD syndrome and normal subjects on serum SOD or LPO levels.(2)Patients with PQD Syndrome,LPO level in BALF was significantly higher,and SOD significantly lower, when compared with normal subjects.(3)Through correlation analysis,it was found in BALF that SOD level was markedly correlated with AM,while LPO was significantly correlated with neutrophil.In short,SOD and LPO in BALF play an important role in the development of the PQD Syndrome,and are good indications in evaluating the PQD Syndrome.

关 键 词：肺气虚证 BALF 中医辩证 SOD LPO 支气管炎 

分 类 号：R259.622.1[医药卫生—中西医结合] R256.102[医药卫生—中医内科学]