益肺抗瘤饮抑制肺癌细胞增殖的实验研究  

Experimental Study on Inhibitory Effect of Yifei Kangliu Decoction on Cell Proliferation of Lung Cancer

作　　者：许玲[1] 刘嘉湘[1] 

机构地区：[1]上海长征医院中医科,上海龙华医院中医肿瘤科

出　　处：《中国中西医结合杂志》1996年第8期486-488,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市高教局资助

摘　　要：本研究应用人肺腺癌ＬＡＸ－８３裸小鼠模型观察益肺抗瘤饮对癌细胞增殖的抑制作用，发现其抑瘤率为４５．５９％。并且益肺抗瘤饮组的Ｋｉ－６７阳性率低、细胞周期中Ｓ期细胞数减少，有统计学差异。益肺抗瘤饮组ｃ－ｍｙｃ蛋白表达、Ｐ５３蛋白表达发生了改变。说明益肺抗瘤饮的抑瘤作用可能是通过改变癌基因的表达，直接影响癌细胞增殖而实现的。In this study, the inhibitory effect of Yifei Kangliu Yin(YFKL) was observed on growth ofLAX-83 human lung adenocarcinoma in naked mice. It was found that the YFKL could suppress the tumor growth significantly with a suppression rate of 40.59%. It was also found that positive expression of Ki-67 and cell proliferation significantly decreased, cmyc changed from positive to weak positive and P53 from positive to negative in the YFKL treated group. It suggested that the iuhibitory effect of YFKL on proliferation of cancer cells might be realized by way of changing the oncogenetic expression of cancer, so as to influence the cell proliferation directly.

关 键 词：益肺抗瘤饮 细胞增殖 肺肿瘤 中医药疗法 

分 类 号：R273.42[医药卫生—中西医结合]