肝素和硫酸乙酰肝素抑制草酸钙结石形成的化学基础  

Chemical Basic of the Inhibition of Calcium Oxalate Stones by Heparin and Heparan Sulfate

作　　者：邓穗平[1] 欧阳健明[1] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,广东广州510632

出　　处：《化学世界》2006年第8期500-503,466,共5页Chemical World

基　　金：国家自然科学基金重点项目(20471024);广东省"千百十工程"优秀人才培养基金(Q02060)

摘　　要：从肝素(HP)和硫酸乙酰肝素(HS)的结构和性质出发,综述了HP和HS对草酸钙(CaOxa)结晶和CaOxa结石形成的影响,并从HP相对分子质量、电荷密度和体系离子强度讨论了影响HP抑制活性的因素。HP不但可以与Ca2+离子结合,降低CaOxa溶液的过饱和度,抑制CaOxa晶体的成核、生长和聚集,而且可以保护尿路粘膜,防止晶体粘附。HS对CaOxa结石形成的作用存在抑制和促进两种不同的观点。In view of the structure and behavior of heparin （HP） and heparan sulfate （HS）, the effect of HP and HS on calcium oxalate （CaOxa） crystallization and CaOxa calculus formation was reviewed. The influence of the relative molecular mass and charge density of HP as well as ionic strength in solution on inhibitory activity of HP was also discussed. It was found that HP not only decreased the supersaturation after binding with calcium ions and inhibited the nucleation, growth and aggregation of CaOxa crystals, but also protected the mucous lining of urinary tract against adherence of crystals on the cellular surface. However, there are arguments about the inhibitive and promotive role of HS on the formation of CaOxa calculus.

关 键 词：结石 肝素 硫酸乙酰肝素 草酸钙 

分 类 号：Q538[生物学—生物化学]