福尔肝健脾软肝方及拆方对CCl_4肝纤维化大鼠肝功能的影响  

Effect of Fuerganjianpiruangan Decoction and Its Seperated Decoction on Liver Function in Rats with Hepatic Fibrosis Induced by CCl_4

作　　者：陈文慧[1] 魏东[1] 唐阁[1] 舒静纹[1] 

机构地区：[1]云南中医学院基础医学院,云南昆明650200

出　　处：《云南中医学院学报》2006年第4期13-16,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：云南省自然科学基金资助(NO:2002C0055M)

摘　　要：目的:观察福尔肝健脾软肝方及拆方对CCl4肝纤维化大鼠肝功能的影响。方法:复制CCl4肝纤维化大鼠模型,观察等效剂量健脾软肝方及拆方灌胃,并以鳖甲软肝片为对照;观察血清肝功能ALT、AST、白蛋白、总蛋白;Jamall氏法检测肝组织羟脯氨酸(hydroxyproline,Hyp)。结果:与正常组大鼠比较,模型组血清ALT、AST明显升高,Alb、TP明显下降,肝组织Hyp含量显著增加,各组动物治疗后,肝功能、肝组织Hyp含量均有不同程度改善或降低,其中健脾软肝方全方组在降低ALT活性、肝组织Hyp含量较其他用药组为好,健脾理气类为主要治法的拆方组能提高白蛋白含量。结论:福尔肝肝健脾软肝方及拆方有良好的改善肝功能、抗肝纤维化作用,尤以健脾软肝方全方组作用为好。Objective： To observe the effect of FuerganJianpiruangan decoction and its separated decoction on liver function in rats with hepatic fibrosis induced by CCl4. Method： Group the SD rats into eight categories randomly： Normal group, Model group, Jianpiruangan group and its separated decoction group. Copy the model of rats with hepatic fibrosis induced by CCl4. In the mean time, fill rats stomach with the same dose of Jianpiruangan decoction and its separated decoction, comparing with the Biejiaryangan pills on a daily basis for six weeks. Observe the Serum alanine aminotransamine （ALT）, aspartate transamine （AST） activity, the amount of TP and albumin （Alb） levels were determined biochemically; Check the Hydroxyproline （Hyp） using Jamall method. Results： Comparing with the rats in the normal group, the amount of Serum ALT, AST in the model group is increasing substantially. The amount of Alb, TP is lowering substantially; while the content of Hyp is increasing. After treatment with medication, the liver function and Hyp is improved or lowered at different levels. Jianpiruangan decoction is better than other groups in lowering the activity of Alt and content of Hyp, separated decoction group with the feature of Jianpiliqi can improve the amount of Alb. Conclusion： FuerganJianpiruangan decoction and its separated decoction play a very important role in the improvement of liver function, anti - hepatic fibrosis among these groups. Jianpiruangan decoction is the most effective.

关 键 词：肝纤维化 四氯化碳 健脾软肝方 肝功能 拆方研究 

分 类 号：R289.5[医药卫生—方剂学]