1,2,4-三唑-3-羧酸甲酯的合成工艺改进  

Improved synthesis of methyl 1,2,4-triazole-3-carboxylate

作　　者：路有昌[1] 张换平[1] 

机构地区：[1]安阳工学院化工系,河南安阳455000

出　　处：《化学试剂》2006年第8期503-504,共2页Chemical Reagents

摘　　要：以草酸二乙酯为原料,经氨解,肼解,环合,醇解,而制得1,2,4-三唑-3-羧酸甲酯。该合成工艺具有步骤少,条件温和,操作简便,污染少,产率较高等优点。Starting from oxalic acid diethyl ester, the synthesis of methyl 1,2,4-triazole-3-carboxylate was improved by aminolysis, hydrazinolysis, cyclization, alcoholysis. The improved synthesis had several advantages such as few procedures, mild reaction conditions easy operation, low contaminstion and high yield of product.

关 键 词：草酸二乙酯 环合 醇解 1 2 4-三唑-3-羧酸甲酯 工艺改进 

分 类 号：O626[理学—有机化学]