磺胺甲基异噁唑的TLC-SERS研究  

Study on the TLC-SERS of Sulfamethoxazole

作　　者：张进治[1] 汪瑗[2] 陈向明[1] 

机构地区：[1]北方工业大学理学院物理系,北京100041 [2]首都师范大学化学系,北京100037

出　　处：《光谱学与光谱分析》2006年第8期1469-1471,共3页Spectroscopy and Spectral Analysis

基　　金：北方工业大学科研基金(2004-0098)资助项目

摘　　要：应用表面增强拉曼光谱技术将薄层色谱(TLC)与FT-Raman光谱联用,对抗菌素磺胺类药物的有效成分磺胺甲基异唑的光谱进行了研究分析。结果表明,在薄层原位仅1μg样品就可获得分子的主要振动谱带。文章还分析了复方磺胺甲基异唑片(复方新诺明片)与对照品谱图的差异,论证了应用表面增强拉曼光谱技术将薄层色谱与FT-Raman光谱联用对医药化学成分进行高灵敏度检测的可行性及优越性。The spectra of sulfamethoxazole, the efficient ingredient of sulfanilamide-like medicine, were investigated by combining the TLC and FT-Raman spectroscopy using the surface enhanced Raman spectroscopy technique. The result indicates that the main vibrant characteristic spectral band can be obtained by TLC in a samples of just about 1 μg. The difference between the compound sulfamethoxazole and the eorresponding spectra picture is analyzed. The analysis shows that the method of combining TLC and FT-Raman spectroscopy by the SERS is practical and advantageous in the highly sensitive measurement of the chemical ingredient in medicine.

关 键 词：磺胺甲基异噁唑 薄层色谱 表面增强拉曼光谱 近红外傅里叶变换拉曼光谱 

分 类 号：O657.3[理学—分析化学]