复方儿茶水提液的毒理学研究  

Study on toxicology of water extration solution of catechu composita

作　　者：谢世荣 高明[2] 孙长滨[3] 陈宏 黄彩云[1] 刘超[3] 刘春晖[1] 任彩霞[1] 

机构地区：[1]大连大学医学院药理学教研室,辽宁大连116622 [2]大连大学医学院中药教研室,辽宁大连116622 [3]大连大学医学院组织胚胎学教研室,辽宁大连116622 [4]齐齐哈尔中医医院药剂科,黑龙江齐齐哈尔161000

出　　处：《大连医科大学学报》2006年第4期282-283,共2页Journal of Dalian Medical University

基　　金：齐齐哈尔市科技局科研基金(2004XKDT-5)

摘　　要：[目的]研究复方儿茶水提液(water extration solution of catechu composita,WESCC)的急性毒性,探讨WESCC的安全性。[方法]应用改良寇氏改良法测定WESCC的半数致死量(LD50)。应用常规法观察WECC对家兔急性皮肤刺激性和急性皮肤毒性。光镜下观察小鼠心、肝、肾组织的形态结构变化。[结果]WESCC的LD50为268 g/kg。WESCC对家兔没有急性皮肤刺激性和急性皮肤毒性。WESCC对小鼠心、肝、肾的形态结构没有改变。[结论]实验结果表明WESCC的低毒性。[ Objective] To study the acute toxicity of water extration solution of catechu composita（WESCC）. To investigate thesafety of WESCC . [ Methods] The LD50 of WESCC in mice was assayed with improved karbers method. The skin stimulation and skin acute toxicity of WESCC in rabbit was observed with routine method. The tissue structural change of heart, hepatic and kidney in mice were observed under light microscope. [ Results] WESCC no toxicosis were observed found in mice （LD50 = 268 g/kg ） and no skin stimulation and no skin acute toxcant take place. WESCC didnt change tissue structural of heart, hepatic and kidney in mice. [Conclusion] WESCC is low toxicity.

关 键 词：复方儿茶水提液 急性毒性 半数致死量 

分 类 号：R285[医药卫生—中药学]