微透析取样技术及其在体内药物分析中的应用  

Microdialysis sampling technique and its application in biopharmaceutical analysis

作　　者：徐铭[1] 李范珠[1] 

机构地区：[1]断江中医药大学药学院,杭州310053

出　　处：《药物分析杂志》2006年第7期1030-1034,共5页Chinese Journal of Pharmaceutical Analysis

基　　金：国家自然科学基金重大研究计划;项目编号:90409012

摘　　要：通过查阅近几年的相关文献,并结合本实验室的相关研究,概述了微透析取样技术的原理和优势,重点介绍了其在体内药物分析中的应用。微透析取样技术能直接对作用部位细胞外液中的药物及其代谢产物进行取样,是体内药物分析的重要工具。此技术在体内药物分析领域具有广阔的应用前景。After consulting the recently literatures about microdialysis sampling technique and the research which has been done in our lab, the principle and advantages of microdialysis sampling technique were reviewed;and its applications in biopharmaceutical analysis were chiefly introduced. Microdialysis sampling technique can collect samples from extracellular fluid of the action site directly and effiectively, and has been an important tool for biopharmaceutical analysis. The prospects of application of microdialysis sampling technique is very wide in the field of biopharmaceutical analysis.

关 键 词：微透析取样技术 体内药物分析 应用 

分 类 号：R917[医药卫生—药物分析学]