老年糖尿病合并冠心病患者血浆高敏C反应蛋白水平的研究  

A study of plasma high sensitive C-reactive protein level in elderly type2 diabetic with coronary heart diseases

作　　者：徐援[1] 张智勇[1] 马利祥[1] 潘永华[1] 苗莉[1] 

机构地区：[1]首都医科大学附属北京朝阳医院内分泌科,北京100020

出　　处：《中国医刊》2006年第8期29-30,共2页Chinese Journal of Medicine

摘　　要：目的探讨血浆高敏C反应蛋白(hs-CRP)水平的变化在老年男性2型糖尿病合并冠心病患者发病中的意义。方法入选冠状动脉造影资料齐全且确诊为冠心病的老年男性患者62例,按有无合并糖尿病分为2型糖尿病合并冠心病组28例,单纯冠心病组32例,测定晨起空腹静脉血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),采用高敏免疫检测方法检测血浆hs-CRP水平,将组间各指标进行比较,并进行多元Logistic回归分析。结果糖尿病合并冠心病组hs-CRP、LDL-C、白细胞计数和血糖显著高于单纯冠心病组(P分别为0.037、0.048、0.011和<0.001)。多元Logistic回归分析显示,与2型糖尿病合并冠心病发病独立相关的因素有hs-CRP(OR=1.39,P=0.008)和血糖(OR=1.02,P=0.012)。结论血浆hs-CRP和血糖水平的升高是老年男性2型糖尿病合并冠心病发生的独立危险因素,炎症过程参与了2型糖尿病合并冠心病的发生和发展。Objective To evaluate the changes of plasma high-sensitivity C-reactive protein （hs-CRP） ＇s level in type2 diabetes （DM）men with coronary heart diseases（CHD）. Methods 62 elderly men with coronary angiography were divided into two groups（ DM with CHD group and CHD group）. The levels of plasma hs-CRP were measured in 28 male with type2 DM and coronary heart disease against control of 32 males with coronary heart diseases. Meanwhile, the levels of serum total cholesterol （TC）, triglyceride （ TG）, low density lipoprotein-cholesterol （ LDL-C ）, high density lipoprotein-cholesterol （HDL-C） ,blood leukocyte and blood sugar were investigated and compared between the groups. Results The levels of hs-CRP,LDL-C ,leukocyte and blood sugar in the group of diabetes with coronary heart disease were significantly higher than those in control group（ P =0. 037,0. 048,0.011 and 〈0.001 respectively ）.＇ Multiple regression analyses identified two independent predictors of the cardiovascular risk （hs-CRP） （ OR = 1.39 ,P = 0.008 ） and blood sugar （OR = 1.02,P =0. 012） ） in type2 DM men with CHD. Conclusion It is shown that the levels of hs-CRP,blood sugar,LDL-C and leukocyte in the group of elderly type2 DM men with CHD were significantly higher than those in the group of non-diabetic men with CHD. Hs-CRP and blood sugar are independent risk factors in type2 DM men with CHD. Plasma hs-CRP, blood sugar,leukocyte and inflammation jointly contribute to the cardiovascular risk in elderly type2 DM men.

关 键 词：C反应蛋白 2型糖尿病 冠状动脉疾病 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]