乙肝患者HBsAg定量与HBV-DNA及乙肝标志物模式的比较分析  

Relationship between quantitative HBsAg by chemiluminescent immunoassay,HBV-DNA and HBV-M in patients with hepatitis B

作　　者：刘灿[1] 翁义锐[1] 陈永东[1] 

机构地区：[1]福建医科大学附属第一医院检验科,350004

出　　处：《福建医药杂志》2006年第4期124-125,共2页Fujian Medical Journal

摘　　要：目的探讨化学发光化法乙肝表面抗原定量测定与HBV-DNA水平及乙肝病毒标志物模式之间的相互关系。方法运用化学发光法、荧光定量PCR(FQ-PCR)及ELISA三种方法同时检测258份血清标本,并对其结果应用统计学方法加以对比分析。结果258份乙肝患者血清HBsAg含量与HBV-DNA及乙肝病毒标志物检测,显示其具有良好的相关性。结论化学发光法定量检测HBsAg能较准确、快速地反映体内乙肝病毒复制情况。Objective To explore the relationship between quantitative HBsAg by chemiluminescent immunoassay （CMIA）, hepatitis B virus （HBV） DNA level and HBV marker （HBV-M）. Methods In sera of 258 patients, HBsAg was detected by CMIA, and HBV-DNA was detected by florescence quantitative PCR （FQ-PCR）, while HBV-M was detected by enzyme linked immuno sorbent assay （ELISA）. Results There were well correlation between HBsAg, HBV-DNA and HBVM in sera of 258 patients. Conclusions The level of HBsAg detected by CMIA can better reflect the replication of HBV.

关 键 词：HBSAG定量 HBV-DNA 乙肝标志物 

分 类 号：R512.62[医药卫生—内科学]