双相迟发多器官功能不全综合征（MODS）动物模型的研究  

A Study of Animal Model of the Delayed Two Phase Multiple Organ Dysfunction Syndrome in Goats

作　　者：胡森 盛志勇 周宝桐 薛丽波 晋桦 于燕 陆江阳 孙晓庆 孙世荣 黎君友 王亚平 祝晓枫 郑玉清 

出　　处：《中华创伤杂志》1996年第2期102-106,共5页Chinese Journal of Trauma

摘　　要：目的：复制符合ＭＯＤＳ发病因素，病理过程和临床特征的标准化动物模型。方法：在提出符合临床实际的ＭＯＤＳ模型标准和建立动物ＩＣＵ的基础上，用创伤失血性休克后门静脉持续输入内毒素的方法；复制出山羊ＭＯＤＳ模型。结果和结论：该模型的致伤因素、发病过程、临床特征及诊断标准都与临床典型的双相迟发ＭＯＤＳ相似，是目前比较理想的和适用于临床防治研究的ＭＯＤＳ动物模型。Aim: To find a standardized animal model that would accurately imitate clinical features of multiple organ dysfunction syndrome (MODS).Methods: Thirty two goats were randomly divided into three groups which were subjected to hemorrhagic shock (group H, n=6), endotoxiemia (group E, n=6) and hemorrhagic shock plus endotoxiemia (group M, n=20) respectively. Hemorrhagic shock was produced according to the method of Wigger (6.7kPa BP for an hour). One hour after shock, reperfusion injury was produced by a rapid infusion of the shed blood and Ringer's solution. Endotoxin (E. coli O 26:B6) was given via the portal vein 24 hours after the resuscitation of hemorrhagic shock, in a dose of 30 ng/kg/min for 5 consecutive days. During the observation period of 10 days, all animals were monitored, given standard metabolic support and due cardiac and pulmonary support according to human intensive care.Results: In group M, 18 animals died, a mortality of 90%, 12 of 18 developed MODS, with a rate of 60% in the whole group, and 71% in animals survived after shock. Most animals in group M developed hyperdynamic circulation, hypermetabolism and systemic inflammatory responses, corresponding the characteristics of MODS. A set of criteria for a standardized animal model of MODS was proposed.Conclusion: It was successful to reproduce the standard large animal model which was very similar in all respects to a delayed two phase MODS of human patients.

关 键 词：多器官功能不全 综合征 诊断 MODS 动物模型 

分 类 号：R59[医药卫生—内科学]