脉络宁注射液治疗缺血性中风急性期随机对照试验的系统评价  

System Evaluation of Randomized Controlled Trial on Mailuoning Injection in Treating Acute Stage of Ischemic Apoplexy

作　　者：李可建[1] 

机构地区：[1]山东中医药大学,济南250014

出　　处：《中华中医药杂志》2006年第8期471-474,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局中医药科学技术研究专项中医临床研究课题(No.04-05LQ03)

摘　　要：目的:系统评价脉络宁注射液治疗缺血性中风急性期的疗效及安全性。方法:搜集脉络宁注射液治疗缺血性中风急性期随机对照试验文献,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta-分析、漏斗图分析、敏感性分析等方法统计相关数据。结果:8项符合纳入标准,采用Jadad评分标准对每篇文章的方法学质量进行评价,试验得分均为1分,属低质量文献;Meta-分析结果显示,与空白对照组比较,总有效率比较相对危险度(RR)合并=1.19,99%可信区间(CI)为(1.09,1.30),病死率比较RR=0.93,99%CI为(0.02,36.07)。结论:本系统评价显示脉络宁注射液治疗缺血性中风急性期有效,且无严重不良反应。Objective： To make a system evaluation on the therapeutic effect and safety of Mailuoning Injection （MI） in treating acute stage of ischemic brain infarction apoplexy （IBIA）. Methods： Literatures about randomized controlled trial （RTC） on MI in treating acute stage of IBIA were collected, and the qualified researches were filtrated. Then made a quality evaluation by Jadad scoring method, and took statistics of the correlated data with the methods of heterogeneity test, Metaanalysis, filler-graph analysis and sensitivity analysis etc. Results： There were eight items accorded with bringing into standard. Then the methodology quality of each articles were evaluated adopting Jadad scoring standard, and the trials each get one score, belonging to low-quality literatures. The analytic results of Meta analysis showed that compared with blank control group, the total effective rate comparison relative risk （RR） to merge equaled 1.19, 99% confidence interval （CI） was （1.09, 1.30）, the case-fatality rate （CFR） comparison relative risk （RR） equaled 0.93, 99% confidence interval （CI） was （10.02, 36.07）. Conclusion： This system evaluation demonstrated that MI was good for treating acute stage of IBIA, and no serious adverse reactions.

关 键 词：脉络宁注射液 缺血性中风 急性期 随机对照试验 系统评价 

分 类 号：R255.2[医药卫生—中医内科学]