黄芩苷注射液体外抗菌作用实验研究  

Experimental Study on Antibacterial Effect of Baicalin Injection in Vitro

作　　者：张喜平[1] 周田美[2] 董晓勤[2] 陈汉卿[3] 

机构地区：[1]浙江省杭州市第一人民医院普外科,310006 [2]杭州市第一人民医院细菌室 [3]浙江中医药大学

出　　处：《医学研究杂志》2006年第8期39-41,共3页Journal of Medical Research

基　　金：浙江省中医药卫生科技计划项目(2003C130);杭州市重大科技发展计划项目(2003123B19);杭州市医药卫生重点项目(2004Z006);杭州市131优秀中青年科技培养人才项目资助

摘　　要：目的探讨黄芩苷注射液的体外抗菌活性。方法采用液体倍比稀释法,测定黄芩苷注射液对临床分离的161株常见病原菌的最低抑菌浓度(MIC)及最低杀菌浓度(MBC)。结果黄芩苷对临床常见病原菌的MIC范围为0.1～50mg/ml,MBC范围0.2～50mg/ml,对葡萄球菌MIC及MBC明显低于其他细菌,MIC范围0.1～6.3mg/ml,MBC范围0.2～12.5,MIC50、MIC90分别为0.4mg/ml、0.8mg/ml。结论黄芩苷注射液对多种病原菌有不同程度的抑菌作用,其中对葡萄球菌抗菌作用最强。Objective To explore the antibacterial activity of the baicalin injection in vitro. Methods The broth doubling dilution method has been adopted. And the minimal inhibitory concentration （MIC） and minimum bactericidal concentration （MBC） of balcalin injection on 161 common pathogenic bacteria obtained from clinical practice were determined. Results The MIC range of baicalin against clinically common pathogenic bacteria is 0.1 - 50mg/ml and the MBC range is 0.2 - 50mg/ml. The MIC and MBC against staphylococci is remarkably lower than those against other bacteria, with the MIC range of 0.1 - 6.3mg/ml and MBC range of 0.2 - 12.5 respectivel. The MIC50, MIC90 are respectively O.4mg/ml and 0.8mg/ml. Conclusions The baicalin injection possesses various levels of inhibitory effect on manifold pathogenic bacteria, especially the antibacterial effect on the staphylococci.

关 键 词：黄芩苷 病原菌 抗菌活性 

分 类 号：R978.11[医药卫生—药品] R286.0[医药卫生—药学]