Characteristics of Baicalin Synergy with Penicillin or Notopterygium Ethanol Extracts Against Staphylococcus aureus  

作　　者：孟甄 郑进燮 游雪甫 邢东明 王伟 杜力军 

机构地区：[1]Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China [2]Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

出　　处：《Tsinghua Science and Technology》2006年第4期459-461,共3页清华大学学报（自然科学版（英文版）

基　　金：Supported by the Basic Research Foundation of Tsinghua University

摘　　要：Baicalin facilitates the effectiveness of both penicillin and Notopterygium ethanol extracts （NEE） on Staphylococcus aureus. Two Staphylococcus aureus strains, ATCC29213 and 03-21 （a clinical isolate）, were tested. When combined with 128 μg.mL^-1 of baicalin, the minimum inhibitory concentration （MIC） of penicillin was reduced from 0.25 μg.mL^-1 to 0.06 μg.mL^-1, while that of NEE was reduced from 32 μg·mL^-1 to 8μg·mL^-1 against ATCC29213. Against the 03-21 strain, the MIC of penicillin was reduced from 4 μg.mL^-1 to 1 μg.mL^-1, while that of NEE was reduced from 32 μg.mL^-1 to 4 μg·mL^-1. Viable number counting results show that combination of baicalin and penicillin acts on the killing mechanism, while the baicalin and NEE acts on the inhibition. These results show that baicalin acts as a synergistic ally with both penicillin and NEE but has different modes of action.Baicalin facilitates the effectiveness of both penicillin and Notopterygium ethanol extracts （NEE） on Staphylococcus aureus. Two Staphylococcus aureus strains, ATCC29213 and 03-21 （a clinical isolate）, were tested. When combined with 128 μg.mL^-1 of baicalin, the minimum inhibitory concentration （MIC） of penicillin was reduced from 0.25 μg.mL^-1 to 0.06 μg.mL^-1, while that of NEE was reduced from 32 μg·mL^-1 to 8μg·mL^-1 against ATCC29213. Against the 03-21 strain, the MIC of penicillin was reduced from 4 μg.mL^-1 to 1 μg.mL^-1, while that of NEE was reduced from 32 μg.mL^-1 to 4 μg·mL^-1. Viable number counting results show that combination of baicalin and penicillin acts on the killing mechanism, while the baicalin and NEE acts on the inhibition. These results show that baicalin acts as a synergistic ally with both penicillin and NEE but has different modes of action.

关 键 词：baicalin synergy minimum inhibitory concentration Staphylococcus aureus 

分 类 号：R96[医药卫生—药理学]