阿奇霉素治疗儿童下呼吸道感染80例疗效及安全性研究  

Clinical Efficacy and Safety of Azithromycin for Injection in Treating Lower Respiratory Tract Infection of Children(80cases)

作　　者：邓颖[1] 胡小娟[1] 于力[1] 张又祥[1] 

机构地区：[1]广东省广州市第一人民医院儿科,510180

出　　处：《实用心脑肺血管病杂志》2006年第5期355-356,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察阿奇霉素(商品名:博抗)针剂对儿童下呼吸道感染的临床疗效及安全性。方法选择下呼吸道感染的患儿134例,分为治疗组80例,对照组54例。治疗组给予博抗8～10mg·kg-1·d-1,1次/d,静脉滴注;对照组给予红霉素20～25mg·kg-1·d-1,1次/d,静脉滴注。疗程均为3～5d。结果治疗组和对照组疗效比较差异有显著性意义(P<0.05)。两组不良反应发生率分别为13.7%和24.1%。两组比较差异有显著性意义(P<0.05)。结论博抗治疗儿童下呼吸道感染性疾病疗效较好,不良反应少,价格便宜,适合儿童应用。Objective To evaluate the clinical efficacy and safety of Azithromycin injection in treating lower respiratory tract infection of children. Methods A total of 134 patients were included in this study, 80 cases treated with Azithromycin were compared with 54 cases treated with Erythromycin. Drugs were administered by intravenous drip once daily for 3 ～ 5 days, at a daily dose of 8 ～ 10mg · kg^- 1 · d^- 1 of Azithromycin Aspartate and 20 ～ 25mg · kg^- 1 · d^- 1 of Erythromycin. Results The overall clinical efficiency rate of Azithromycin Aspartate was 90.0%, and that of Erythromycin was 79.6%. There was significant difference （ P 〈0.05）. The incidence of adverse drug reactions for Azithromycin Aspartate was lower than that for Erythromycin. Conclusion Azithromycin Aspartate is an effective antibiotic for the treatment of lower respiratory tract infection in children.

关 键 词：阿奇霉素 呼吸道感染 治疗结果 

分 类 号：R725.6[医药卫生—儿科]