抗HBc-IgM、前S_1抗原与HBV-DNA检测在乙肝诊断中的相关性研究  

The Correlation Research on Anti-HBc-IgM,Pre-S_1 Antigen and HBV-DNA Detection in the Diagnosis of Hepatitis B

作　　者：张健[1] 庞新华[1] 李秀青[1] 董海新[1] 窦翠云[1] 山锋[1] 刘晓钟[1] 

机构地区：[1]济宁医学院附属医院,山东省市济宁市272129

出　　处：《实用心脑肺血管病杂志》2006年第7期535-536,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的通过对乙肝最常见的大三阳和小三阳患者进行抗HBc—IgM、前S_1抗原及HBV—DNA检测,找出三项指标的相关性。方法取大三阳和小三阳患者各100例进行抗HBc—IgM、前S_1抗原及HBV—DNA荧光定量检测,并进行统计学分析。结果前S_1抗原与HBV—DNA荧光定量检测对乙肝复制检测有相关性。抗HBc-IgM与乙肝大三阳和小三阳存在密切关系。结论大三阳和小三阳的抗HBc—IgM、前S_1抗原及HBV—DNA,三项指标阳性率不同,反映的临床意义也不同,对乙肝患者不能只是诊断了大三阳或小三阳,还应进行抗HBc—IgM与前S_1抗原检测尤其进行HBV—DNA荧光定量检测,并进行长期随访研究。Objective To find the correlation of the Anti - HBc - IgM, pre - S1 Antigen and HBV - DNA detection with the two common types of hepatitis B type. Methods 100 patients with HbsAg/eAg/cAb positive were selected as the big three positive group, and 100 patients with HbsAg/eAb/cAb positive as the small three group, then examine and statistically analyse their Anti - HBc - IgM, pre - S1 antigen and HBV - DNA. Results Anti - HBc - IgM and pre - S1 have correlation with the virus copy of hepatitis B type. HBe - IgM is relative to two common types of hepatitis B type. Conclusion Quantitative examination of Anti - HBc - IgM, pre - S1 antigen and HBV - DNA should be conducted to help diagnose the type of hepatitis B type and applied to long -term follow -up.

关 键 词：抗HBC-IGM 前S1抗原 HBV-DNA 肝炎 乙型 

分 类 号：R512.62[医药卫生—内科学]