冠心苏合丸系列组方的比较药理学研究  

Study on comparative pharmacology of series of Muskone

作　　者：马堃[1] 张金艳[1] 李贻奎[1] 张永涛[1] 吴理茂[2] 李向日[3] 潘理[4] 李连达[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]浙江大学药学院,浙江杭州310031 [3]北京同仁堂股份有限公司科学研究所,北京100011 [4]沈阳中药制药有限公司,辽宁沈阳110044

出　　处：《中国中药杂志》2006年第16期1353-1357,共5页China Journal of Chinese Materia Medica

摘　　要：目的:研究冠心苏合丸系列组方对急性心肌梗死和疼痛的治疗作用。方法:冠状动脉结扎法制作心肌梗死模型,通过心肌梗死面积的定量组织学测定和血栓素(TXB2)、内皮素(ET)、6-酮-前列腺素(6-keto-PGF1α)检查、评价冠心苏合丸系列组方治疗心肌梗死的作用;腹腔注射醋酸法制作小鼠疼痛模型,观察小鼠扭体次数和潜伏期,评价其止痛作用。结果:含青木香的冠心苏合丸、含土木香的冠心苏合丸和不含青、土木香的冠心苏合丸显著减小大鼠心肌梗死范围,降低TXB2水平和ET水平;提高6-keto-PGF1α水平和6-keto-PGF1/αTXB2比值,显著抑制小鼠疼痛;单方青木香和土木香有减缓疼痛的作用。结论:含青木香、含土木香的冠心苏合丸和不含青、土木香的冠心苏合丸对心肌梗死和疼痛均有显著的治疗作用,单方青木香和土木香主要作用是减缓疼痛。Objective： To study the therapeutic effects of the series of Muskone （the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutehmanspipe Root） on experimental myocardial infarct and pain in rats. Method： Coronary artery ligation was applied for the model of myocardial infarct. Therapeutic effects were evaluated by measuring parameters of histomorphometry, blood plasm of ET, 6-keto-PGF1α and TXB2 . Intraperitoneal injection acetic was applied for the model of ache, the frequency and eclipse period of writhing were evaluated its effect of resisting pain. Result： The Muskone including Radix Aristoleciae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all can decrease the area of myocardial infarction in rats,the level of TXB2, ET, and the frequency of writhing significantly. Also it can increase the level 6-keto-PGF1α, the ratio of 6-keto-PGF1α and TXB2. Single Radix Aristoleciae or Radix Inulae only relieved pain. Conclusion： The Muskone including Radix Aristoleciae, the Muskone including Radix Innlae and the Muskone without Radix Aucklandiae all have significant therapeutic effect on both myocardial infarction and pain, while single Radix Aristoleciae or Radix Innlae only can relieve pain.

关 键 词：冠心苏合丸系列组方 比较药理学 马兜铃酸 青木香 土木香 

分 类 号：R285.5[医药卫生—中药学]