手性二氧大环多胺对苦杏仁酸的手性识别研究  

The Chiral Recognition of Mandelic Acid Using Chiral Dioxocyclen

作　　者：袁泉[1] 谢征[1] 傅恩琴[2] 吴成泰[2] 

机构地区：[1]武汉理工大学理学院应用化学系,湖北武汉430070 [2]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《化学与生物工程》2006年第8期21-23,共3页Chemistry & Bioengineering

摘　　要：以自合成的手性二氧大环多胺作为手性溶解剂,采用NMR技术对苦杏仁酸进行手性识别研究。当主客体混合后,主客体的质子峰在1HNMR图谱中均发生不同程度的化学位移,且苦杏仁酸的α-次甲基氢的化学位移变化值在主客体摩尔比为1∶1时达到最大,从而表明主客体之间可能形成了较为稳定的摩尔比为1∶1的超分子复合物。这一研究结果表明手性二氧大环多胺与苦杏仁酸具有较强的超分子作用,可用于苦杏仁酸的手性识别及对映体拆分。NMR technique is undertaken to study the chiral recognition between mandelic acid and chiral dioxocyclen synthesized by ourselves. Different chemical shifts are shown in the HNMR. From the NMR results, the methine of madelic acid gives the biggest chemical shift while mixed with chiral dioxocyclen Comparing with other complexes formed by host-guest molecules with different molar ratio. It reveals that the mandelic and dioxocyclen form a supramolecular complex with chemical equivalent 1 ： 1. The chiral dioxocyclen shows discriminated supramolecular abilities to madelic acid and may be used as chiral selector in resolution.

关 键 词：手性二氧大环多胺 苦杏仁酸 NMR 手性识剐 

分 类 号：O656.22[理学—分析化学]