住院精神病患者HBV与HCV感染状况调查  

Investigation of Hepatitis B and C Virus Infection among Inpatients with Psychosis

作　　者：常学润[1] 李智强[1] 王丽[2] 郭季磊[1] 李伟[1] 

机构地区：[1]山东省精神卫生中心,山东济南250014 [2]山东省济南市传染病医院,山东济南250021

出　　处：《预防医学论坛》2006年第5期526-527,共2页Preventive Medicine Tribune

摘　　要：[目的]了解住院精神病患者HBV与HCV感染状况,为制订减少HBV、HCV在医院的传播措施提供依据。[方法]对2003年6月至2005年6月住入山东省精神卫生中心的3 896例精神病患者,检测HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc、抗-HCV,抗-HCV阳性结果者再进行HCV RNA定量测定,并以4 191名体检者为对照。[结果]HBV阳性率,3 896例住院精神病患者为60.99%,4 191名健康体检者为44.35%(P<0.01);HCV感染率住院精神病患者为0.82%,健康体检者为0.45%(P<0.05);HBV阳性率和HCV感染率,3 108名精神分裂症患者分别为60.55%、0.80%,其他精神病患者分别为61.43%、0.89%(P>0.05)。3 896例精神病患者中,HBsAg、HBeAg、抗-HBc阳性的占4.96%,HBsAg、抗-HBe、抗-HBc阳性的占4.70%,HBsAg、抗-HBc阳性的占3.99%,抗-HBs、抗-HBc阳性的占22.23%,抗-HBc阳性的占12.73%,抗-HBs、抗-HBe、抗-HBc阳性的占9.03%,抗-HBe、抗-HBc阳性的占3.31%,抗-HCV阳性的占0.77%,抗-HBs、抗-HCV阳性的和抗-HBc、抗-HCV阳性的各占0.03%。[结论]精神病人HBV、HCV感染率较高。[Objective]To explore the infectious situation of HBV and HCV for inpatients with psychosis and provide the data for prevention and control of heapititis B and C in hospital. [Methods]From June,2003 to June,2005,3 896 inpatients in Shandong Mental Health Center and 4 191 normal controls were involved in this study. ELISA was used to test HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc, and anti-HCV for the subjects. The subjects whose anti-HCV was positive were retested for amount of virus. [Results]The infectious rate of HBV in 3 896 inpatients with psychosis was 60.99 %, that of 4 191 normal persons was 44.35% （ P 〈0. 01） ;The infectious rate of HCV in the inpatients with psychosis was 0. 82% ,that of the normal control group was 0.45%（ P 〈0. 05） ;The infectious rate of 3 108 Schizophrena for HBV and HCV were 60. 55% and 0.80% respectively,and those of patients with other mental disorders were 62.69% and 0.89% （ P 〉0. 05）. In 3 896 inpatients,the rate of the model with HBsAg, HBeAg and anti-HBc positive was 4.96% ,the rate of the model with HBsAg,anti-HBe and anti-HBc positive was 4. 70% ,the rate of the model with HBsAg and anti-HBc positive was 3.99 %, the positive rate of both anti-HBs and anti-HBc positive was 22.23 %, the positive rate of anti-HBc positive was 12.73 %, the rate of the model with anti-HBs, anti-HBe and anti-HBc positive was 9.03 %, the positive rate of anti-HBe and anti-HBc was 3.31%, the positive rate of anti-HCV was 0.77%, the rates of anti-HBs and anti-HCV, anti HBc and anti-HCV were all 0.03 %. [Conclusion]The infection rate of HBV and HCV in the patients with psychosis were higher.

关 键 词：精神病患者 HBV HCV 感染 

分 类 号：R512.6[医药卫生—内科学]