用于检测呼吸道复温的低体温犬模型的建立  

ESTABLISHMENT OF A HYPOTHERMIC DOG MODEL TO INVESTIGATE AIRWAY REWARMING

作　　者：刘嘉瀛[1] 杨增仁[1] 颜培华[1] 孙方人[1] 单秋玲[1] 李郁卿[1] 

机构地区：[1]军事医学科学院卫生学环境医学研究所,天津300050

出　　处：《中国应用生理学杂志》2006年第3期375-378,共4页Chinese Journal of Applied Physiology

摘　　要：目的:为开展低体温复温方法和装备研究,建立了抑制寒颤的低体温犬模型。方法:使用热电偶测温仪测定受试犬体心温度和皮肤温度,将麻醉受试犬浸泡在16.7℃水中直至食道温度降至34.0℃,受试犬出水后待体心温度基本稳定时静脉注射骨骼肌松弛剂卡肌宁,建立抑制寒颤的低体温犬模型。结果:低体温犬的体心温度可用直肠温度或食道温度表示,但二者不可混用。卡肌宁可排除寒颤对单纯呼吸道复温的影响,抑制寒颤的低体温犬模型可用于呼吸道复温方法或装备的检测。结论:建立的低体温犬模型可排除寒颤干扰、重复性好,实验条件简单,便于使用。Aim： In order to study airway rewarming method and rewarming devices for hypothermia, hypotherraic dog model was established. Methods： The anesthetized dog was immersed in cold water at 16.7℃ until the esophageal temperature （Te） of the dog decreased to 34.0℃, the core temperature and skin temperature were monitored by using a 12-channel scanning thermometers. Atracurium besylate, a skeletal muscle relaxant, was injected intravenously when the core temperature of the dog was basically steady after the dog was out of the cold water, the hypothermic dog model was established. Results： Rectal and esophageal temperature could stand for the core temperature of the hypotherrnic dog model, but mixing with each other was prohibited because of leading to mistakes. Administering of atracurium besylate could eliminate the effect of shivering on airway rewarming alone, hypothermic dog model in which shivering was inhibited could be used in determination of airway rewarming technique and rewarming devices for hypothermia. Conclusion： Hypothermic dog model in which shivering was inhibited can abolish the interference of shivering, experimental repeatability is good, experimental method quite simple, and the model appropriates for application and dissemination.

关 键 词：低体温 复温 寒颤 体心温度 

分 类 号：Q494[生物学—生理学] R594.2[医药卫生—内科学]