卵胞质移植——问题和展望(英文)  

Ooplasmic transfer:problems and prospects

作　　者：董为人[1] 仇欣霞[1] 陈英华[1] 赵冰雷[1] 

机构地区：[1]南方医科大学组织胚胎学教研室,广东广州510515

出　　处：《南方医科大学学报》2006年第8期1079-1082,共4页Journal of Southern Medical University

基　　金：Supported by Natural Science Foundation of Guangdong Province(010599, 05004719)

摘　　要：人类卵细胞间的胞质转移最近作为人类辅助生殖生物技术的手段并成为研究热点。许多研究表明线粒体对卵母细胞的受精和胚胎发育有显著影响。但是, 卵胞质转移伴随着DNA异质即线粒体的异质性。本文对国内外近年来卵胞质转移的研究进展进行综述, 并结合克隆技术对其进一步的发展提出自己的见解—逆克隆技术。Cytoplasmic transfer between human oocytes, which represents a complete cytoplasmic exchange, has been performed recently as a means to improve the outcome of assisted reproduction and becomes a hotspot of researches. Many studies have indicated that mitochondria in the oocytoplasm obviously affect fertilization of the oocytes and early embryo development. However, ooplasmic transfer can lead to mitochondrial DNA heteroplasmy and the prospect of mitochondrial heteroplasmy and its potential problems necessitate further studies. The authors reviews the ooplasmic transfer, the relation between ooplasm and fertilization and embryo development, and the mitochondrial heteroplasmy. The authors also propose a new theory of ＂reverse cloning technique＂.

关 键 词：卵胞质移植 线粒体的异质性 胚胎发育 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]