三种前列腺素类药物降眼压效果比较  

A comparison of the ocular hypotensive efficacy of three prostaglandin analogs

作　　者：孔祥梅[1] 孙兴怀[1] 孟樊荣[1] 钱韶红[1] 金晓红[1] 刘淳诗[1] 茅凤英[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《眼视光学杂志》2006年第4期228-230,共3页Chinese Journal of Optometry & Ophthalmology

摘　　要：目的比较拉坦前列素、曲伏前列素和贝美前列素三种前列腺素类药物的降眼压效果。方法选取原发性开角型青光眼和高眼压症患者,拉坦前列素组51例(51眼),曲伏前列素组24例(24眼),贝美前列素组27例(27眼),分别使用相应滴眼液,均为每日1次,共观察4周,测量用药前后的眼压值。结果三组患者用药4周后眼压均有明显下降,拉坦前列素组在8:30测得平均眼压从(24.57±3.68)mmHg(1 mmHg=0.133 kPa)降至(15.29±2.67)mmHg,下降幅度(用药前后眼压差值/用药前眼压值)为37.8%;曲伏前列素组从(24.54±2.95)mmHg降至(16.29±3.11)mmHg,下降幅度为33.6%;贝美前列素组从(25.41±3.63)mmHg降至(16.00±4.45)mmHg,下降幅度为37.0%。用药前及用药后三组间眼压值比较,差异均无显著性(分别为F=0.579、P=0.562;F=0.868、P=0.423)。结论拉坦前列素、曲伏前列素、贝美前列素滴眼液对于原发性开角型青光眼和高眼压症患者都有明显、持久的降眼压作用,且降眼压作用相互间没有明显差异。Objective To compare the ocular hypotensive efficacy of tanoprost, travoprost and bimatoprost. Methods Patients with primary open angle glaucoma（POAG） or ocular hypertension（OHT） were selected for the study. Fitly-one patients were. trcated once daily with latanoprost,24 patients were treated with travoprost and 27 patients were treated with bimatoprost for 4 weeks. Intraocular pressure （IOP） before and after the treatments was observed. Results The IOPs of all patients in the 3 groups had decresed markedly after 4 weeks. The daily average IOP （mean ± standard deviation） at 8：30 in the latanoprost group decreased from（24.57±3.68）mmHg （1 mmHg=0.133 kPa） to （15.29±2.67）mmHg, and the maximum extent of the deerease was 37.8 % ; IOP in the travoprost group decreased from （24.54±2.95）mmHg to （16.29±3.11）mmHg, with a maximum decrease of 33.6%; and the reduction in the bimatoprost group was from （25.41 ± 3.63）mmHg to （16.00 ± 4.45） mmHg,with a maximum decrease of 37.0%. The. effectiveness of the treatmeats did not differ significantly （ F = 0. 579 , P = 0. 562 ; F = 0. 868 , P = 0. 423 ） when the three groups were compared. Conclusion This study demonstrated that latanoprost, travoprost and bimatoprost are. all effective and lasting in reducing IOP in POAG and OHT. The 3 treatments do not differ significantly in their effectiveness.

关 键 词：拉坦前列素/治疗应用 曲伏前列素/治疗应用 贝美前列素/治疗应用 青光眼/药物疗法 高眼压/药物疗法 

分 类 号：R96[医药卫生—药理学]