ER基因多态性与中国南方妇女绝经后骨质疏松症的病例-对照研究  

A case-control study on ER gene polymorphisms and postmenopausal osteoporosis in Southern Chinese women

作　　者：扶世杰[1] 王旭生[1] 唐三元[2] 张先安[2] 黄卫[2] 伍光辉[2] 黄家骏[1] 

机构地区：[1]泸州医学院附属第二医院骨科,四川646000 [2]暨南大学附属第三医院外一科

出　　处：《中国骨质疏松杂志》2006年第4期346-349,共4页Chinese Journal of Osteoporosis

摘　　要：目的对中国南方绝经后妇女中雌激素受体基因PvuⅡ和XbaⅠ核酸限制性内切酶多态性与骨质疏松症的关系进行了病例对照调查。方法中国南方绝经后妇女182人,分为骨质疏松组和正常对照组,每组91人;均用DEXA检测骨密度,用PCRRFLP的方法鉴定雌激素受体的基因型,分析雌激素受体基因多态性与骨密度的关系及各基因型在骨质疏松组与对照组的分布。结果PP、xx、Ppxx、PPxx型在骨质疏松组中的分布频率高于正常对照组,差异有统计学意义。PP、xx、Ppxx、PPxx四种基因型的携带者比正常人骨质疏松的易患程度分别高2.46、2.972、2.2、15倍。结论可以将ER基因PvuⅡ和XbaⅠ多态性作为在中国南方进行筛选绝经后骨质疏松症的高危人群的依据之一。Objective To investigate the relationship between the ER gene polymorphisms Pvu Ⅱ and Xba Ⅰ restriction fragment length polymorphisms （RFLP） and postmenopausal osteoporosis （OP） in Southern Chinese postmenopausal women. Methods A case-control study was conducted. BMD were measured in 182 Southern Chinese postmenopausal women （91 in the OP group and 91 in the control group） by duel energy X-ray absorptionary. The relationship between polymorphisms of ER genotype and BMD, the distribution of ER genotype were evaluated. Results The distribution of PP, xx, Ppxx and PPxx genotype in OP group were significantly higher than that in the control group （OR = 2.46,2.97,2.20 and 15 respectively）. Conclusions Pvu Ⅱ and Xba Ⅰ of the ER gene can be one of the evidences for screening high risk population for OP in Southern Chinese postmenopausal women.

关 键 词：绝经后骨质疏松症 雌激素受体基因 多态性 

分 类 号：R681[医药卫生—骨科学] R734.2[医药卫生—外科学]