口腔负压对咽炎的干预效应及对甲襞微循环变化的影响(英文)  

Interventional effect of oral negative pressure on chronic pharyngitis and its influence on nail fold microcirculation

作　　者：李荣[1] 车建斌[1] 张健[2] 牧晓鸿[1] 刘艳凯[1] 

机构地区：[1]河北北方学院病理生理教研室,河北省张家口市075029 [2]河北建筑工程学院校医院,河北省张家口市075000

出　　处：《中国临床康复》2006年第36期173-175,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:咽部的微循环障碍可能是促使慢性咽炎反复发作的一个发病学基础,而负压治疗能通过生物力学的变化,改善炎症靶器官的微循环。目的:观察口腔负压对慢性咽炎患者的症状和甲襞微循环的改善效果。设计:随机单盲对照观察。单位:河北北方学院病理生理教研室。对象:2002-01/09河北北方学院附属第一医院耳鼻咽喉科收治慢性咽炎患者65例;病程1～3年。随机分为治疗组(n=35)和对照组(n=30)。其中,慢性单纯性咽炎36例(治疗组18例,对照组18例),慢性肥厚性咽炎29例(治疗组17例,对照组12例)。方法:应用Hices口腔负压仪,将负压施加器放入口腔的最适位置,调节负压维持在(0.05±0.01)MPa。治疗时间10min/次(首次5min),1次/d,时间固定,5d为1个疗程,共3个疗程。对照组同样口含负压施加器10min/次,但不给负压。主要观察指标:①甲襞微循环观察与评价:应用XTL-Ⅱ型微循环显微电视系统进行甲襞微循环观察,常规检查左手无名指甲襞第一排管袢,记录微血管形态、微血流状态和袢周状态,按田牛等加权积分法对微循环障碍程度进行定量分析,积分值低说明微循环状态良好。②治疗3个疗程后的咽炎症状改善情况。结果:65例均进入结果分析。①治疗组负压治疗1个疗程后,1/3患者症状显著改善;3个疗程结束后,除咽后壁淋巴滤泡增生及咽侧索增厚等增生性形态学变化未见显著改善外,症状及咽部黏膜充血体征的出现率均显著低于治疗前及对照组(P<0.05～0.01)总有效率为89%。②负压使治疗组慢性咽炎患者微循环障碍明显改善,由治疗前的中度异常恢复到大致正常,总积分值由4.836±0.242降低至1.941±0.165(P<0.01)。结论:口腔负压能明显缓解或消除慢性咽炎的症状和体征,其机制可能与改善微循环障碍有关。BACKGROUND： Microcirculation diSturbance of pharynx may be one of the pathogenesis base caused recurrent attacks of chronic pharyngitis. The negative pressure can improve the microcirculation of inflammary target organs by biomechanical changes, OBJECTIVE： To explore the therapeutic effect of oral negative pressure on patients with chronic pharyngitis and nail fold microcirculation, DESIGN： A randomized single blind controlled observation, SETTING： Department of Pathophysiology of Hebei North University, PARTICIPANTS： A total of 65 patients with chronic pharyngitis and course of disease about 1-3 years admitted to Department of Neurology, First affiliated Hospital of Hebei North University from January to September 2002 were selected. They were randomly divided into treatment group （n=35） and control group （n=30）, including 36 cases with chronic pharyngitis （18 cases from the treatment group, 18 cases from the control group）, 29 with chronic hypertrophied pharyngitis （17 cases from the treatment group, 12 cases from the control group）. METHODS： The Hices oral negative pressure instrument was used and the negative pressure exert equipment was put into the optimal position of the patients＇ mouth to keep the negative pressure of （0.05±0.01） MPa, 10 minutes once （the first therapy time was 5 minutes）, once daily and the time was fixed, 5 days as a period of therapy for three periods, Patients in the control group were also given the negative pressure exerts equipment, but no negative pressure was exerted. MAIN OUTCOME MEASURES： ①Observation and evaluation of nail fold microcirculation： The nail fold microcirculation was observed by the XTL-Ⅱ microcirculation micro-television system, and the first row nail fold of the left ring figure was checked conventionally to record the state of microvessel, state of micro-bloodstream and peri-loop. The degree of microcirculatory disturbance was quantitatively analyzed according to Tian Niu＇s weighing integral method, the lower the

关 键 词：咽炎 微循环 口腔 

分 类 号：R766.14[医药卫生—耳鼻咽喉科]