生姜有效部位对实验性高脂血症大鼠血管内皮的保护作用  

Protective Effect of Effective Parts of Zingiber Offecinal on Vascular Endothelium of the Experimental Hyperlipidemic Rats

作　　者：武彩霞[1] 魏欣冰[1] 丁华[1] 孙霞[1] 程秀民[2] 

机构地区：[1]山东大学医学院药理学研究所 [2]山东大学药学院,山东济南250012

出　　处：《中药材》2006年第8期810-813,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助项目(30271584);山东省自然科学基金资助项目(Y2000C13)

摘　　要：目的:观察生姜有效部位(EPZ)对高脂血症大鼠血管内皮形态学改变及血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)的影响,探讨其保护血管内皮的机制。方法:以高脂饲料喂养大鼠,造成高脂血症模型,同时每天灌服生姜有效部位(主要成分为姜辣素及挥发油)200 mg/kg、400 mg/kg、800 mg/kg,连续13 w。取血,放射免疫法测定血清中IL-6、TNF-α的水平。分离并剪取胸主动脉和腹主动脉观察其血管内皮形态的改变,并测定主动脉内膜中膜厚度(IMT)。结果:生姜有效部位能显著改善高脂血症造成的血管内皮损伤,降低IMT,但对血清中IL-6、TNF-α无显著影响。结论:生姜有效部位能保护血管内皮细胞,但未能明显影响血清炎症因子IL-6、TNF-α的水平。Objective ： To observe the influence of effective parts of Zingiber Officinale on serum IL-6,TNF-α in oroler to investigate the protctive effects of the effective parts of Zingiber Officinal （EPZ） on endothelium of the experimental hyperlipidemic rats and the mechanism of its effects. Methods ： The hyperlipidemia model of rats was constructed by feeding high-fat forage and filled with the effective parts of Zingiber Officinale 200mg/kg,400 mg/kg,800 mg/kg every day for 13 weeks. Blood was drawn to determine both the level of serum IL-6 and TNF-α. All the aortaes were taken to oberserve morphologic change and the intima-media thickness were detected. Results ： The effective parts of Zingiber Officinale could markedly decrease intima-media thickness, but had no marked influence in the level of serum IL-6 and TNF-α. Conclusion ： The Effect Parts of Zingiber Officinale has the effect of protection of the endothelia of hyperlipidemia rats, which has nothing with the level of serum IL-6 and TNF-α.

关 键 词：生姜有效部位 高脂血症 大鼠 血管内皮 炎症因子 主动脉内膜中膜厚度 

分 类 号：R285.5[医药卫生—中药学]