新生儿血清S-100蛋白水平与脑损伤的关系  

The relationship between Serum S-100 protein and brain injury in newborn

作　　者：郭炯光 洪小杨[2] 钱淑鸯[2] 彭永正[2] 王斌[2] 

机构地区：[1]广东省东莞市中堂医院儿科,523220 [2]南方医科大学珠江医院儿科

出　　处：《中国现代医药杂志》2006年第8期38-39,共2页Modern Medicine Journal of China

摘　　要：目的探讨新生儿缺氧缺血性脑损伤血液中S-100蛋白的变化及其与预后的关系。方法出生后24～48h新生儿26例采集血标本各1份,检测其S-100蛋白含量,1周左右行头颅CT检查。结果影像学检查阳性与阴性两组血清S-100蛋白水平分别为1.24±0.57μg/L、0.51±0.12μg/L,两组间有显著差异(P<0.01),血清S-100水平与出生后1分钟Apgar评分呈负相关(r=-0.471,P<0.05)。结论S-100蛋白可作为临床早期评价新生儿脑损伤严重程度及预后的敏感指标。Objective To explore the serum S-100 protein after brain injury and its relationship with clinical data and prognosis in newborn. Methods The serum S-100 concentrations were detected in 26 newborns within 24-48 hours after neonatus were born.A cranial computed tomography （CCT） was performed in a week. Results The serum S-100 concentrations of positive CCT group were 1.24±0.57μg/L and negative group were 0.51 ±0.12μg/L, P〈0.01. S-100 values were significantly correlated with the 1 min Apgar scores（r=0.471 ,P〈0.05）. Conclusion S-100 in serum can be used as a early sensitive marker of brain damage levels and prognosis in newborn.

关 键 词：新生儿 S-100蛋白 脑损伤 APGAR评分 

分 类 号：R722.12[医药卫生—儿科] R446.112[医药卫生—临床医学]