急性心肌梗死溶栓后检测肌红蛋白、肌钙蛋白I、肌酸激酶同工酶对冠脉再通的诊断价值  

Diagnostic value of myoglobin, troponin I and creatine MB in coronary reperfusion of AMI

作　　者：王树源[1] 吴振梅[1] 邓斌[1] 刘明[1] 黄仕洲[1] 

机构地区：[1]广东省肇庆市第一人民医院心血管内科,526021

出　　处：《中国现代医药杂志》2006年第8期48-50,共3页Modern Medicine Journal of China

摘　　要：目的探讨血清肌红蛋白(Mb)、肌钙蛋白I(cTnI)和肌酸激酶同工酶(CK-MB)对急性心肌梗死溶栓冠脉再通的早期诊断价值。方法应用酶联免疫分析法测定106例急性心肌梗死患者溶栓治疗后Mb、cTnI、CK-MB浓度的变化,分析急性心肌梗死患者溶栓再通组(73例)和溶栓未通组(33例)上述指标的变化。结果急性心肌梗死溶栓再通组Mb、cTnI和CK-MB达到峰值浓度的时间较未通组明显提前(P<0.05),其中Mb较cTnI、CK-MB峰值出现更早,分别为(5.9±2.5)h、(14.5±3.2)h和(14.8±3.9)h(P<0.01);Mb、cTnI和CK-MB对判断冠脉再通的敏感性、特异性、预测值无显著性差异(P>0.05)。结论血清Mb、cTnI和CK-MB可以较好地预测急性心肌梗死患者溶栓再通,其中Mb较cTnI、CK-MB能更早的判定冠状动脉是否再灌注。Objective To evaluate the diagnostic value of serum myoglobin, troponin Ⅰ and creatine MB in coronary reperfusion of AMI. Methods Mb,cTnⅠ and CK-MB were measured dynamically by ELISA method in 106 patients treated with thrombolysis .According to clinical criteria,all patients were divided into coronary artery recanalization group and no-coronary artery recanalization group. Results The time to reach peak value of Mb,cTnI and CK-MB were earlier in the patients who reperfused than those of patients who unreperfused,and Mb was earlier than cTnⅠ and CK-MB.The sensitivity,singularity and predictive value in Mb,cTnI and CK-MB were no significant difference （P〉0.05）. Conclusion Mb,cTnI and CK-MB can be an early parameters for judging coronary artery recanalization,Mb can earlier judged coronary reperfusion than cTnⅠ and CK-MB in patients with AMI treated with thrombolysis.

关 键 词：急性心肌梗死 肌红蛋白 肌钙蛋白Ⅰ 肌酸激酶同工酶 溶栓 

分 类 号：R542.22[医药卫生—心血管疾病] R587.104[医药卫生—内科学]