急性心肌梗塞再灌注治疗方法和时间对心肌存活指数的影响  被引量:2

Effects of reperfusion method and time on myocardium survival index in acute myocardial infarction

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作  者:方永祥[1] 张小红[1] 容志毅[1] 何建桂[2] 

机构地区:[1]郴州市第一人民医院心内科,湖南郴州423000 [2]中山大学附属第一医院CCU

出  处:《心血管康复医学杂志》2006年第4期348-350,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘  要:目的:探讨急性心肌梗塞患者再灌注治疗方法和时间对心肌存活指数的影响。方法:178例心肌梗塞病人中89例用冠脉支架治疗,89例采用溶栓治疗。再根据发病至再灌注治疗时间的不同.每组病人再分为3个亚组:短时间组(〈3h),中等时间组(〉3h~〈5h).长时间组(〉5h)。用心肌显像检查评价存活心肌。结果:在溶栓组,低时间组的心肌存活指数[中位数(第25,75百分位数)是[0.45(0.16;0.83)],在中间组为0.29(0.17.0.48),在长时间组为0.20(0.04,0.46)(P〈0.05)。而在支架组中,存活数在低时间组为0.56(0.49,0.75).在中间组为0:57(0.36,0.73),长时间组为0.57(0.32,0.75),P〉0.05。支架组中、长时间段的心肌存活指数显著高于溶栓组(P〈0.001)。结论:对于心肌梗塞12h以内的病人,支架治疗优于溶栓治疗。Objective: To explore the relationship between myoeardium survival index and time interval from onset to treatment in patients with acute myocardial infarction (AMI) treated with coronary artery stenting or thrombolysis. Methods: The 178 AMI patients were randomily divided into coronary stenting group (89 patients) or thrombolysis group (89 patients). Patients of two groups also were divided into following 3 sub-groups defined by time interval from onset to treatment : lower time interval (〈3 h), middle time interval (3 h to 5h), and upper time interval (〉 5 h). Paired seintigraphie examinations were performed to obtain myocardial survival index. Results:In the thrombolysis group, the myoeardium survival index [median (25th; 75th) percentile] was 0.45 (0.16: 0.83) in the lower time interval, 0.29 (0. 17: 0.48) in the middle time interval, and 0.20 (0.04: 0.46) in the upper time interval (P〈 0.05). In the stenting group, the survival index was 0.56(0.49; 0. 75) in the lower, 0.57 (0.36; 0. 73) in the middle, and 0.57 (0.32; 0.75) in the upper interval (P=0.59). The myoeardium survival index of middle, upper time interval in AMI patients treated with stenting was better than those of thrombolysis (P〈0. 001). Conclusion: The therapeutic effects of stent implanted in 12 h from onset to treatment are better than those of thrombolysis.

关 键 词:心肌梗塞 支架 血栓溶解疗法 放像性核素显像 

分 类 号:R542.22[医药卫生—心血管疾病]

 

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