AG490对心肌营养素-1致心肌细胞肥大的影响  

Effect of AG490 on hypertrophy of cardiomyocytes induced by cardiotrophin-1

作　　者：杨爽[1] 杨凯[2] 陆莹[3] 于波[1] 

机构地区：[1]哈尔滨医科大学附属第二医院心内科 [2]哈尔滨理工大学医院检验科 [3]哈尔滨医科大学附属第二医院急诊科

出　　处：《心血管康复医学杂志》2006年第4期353-355,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究AG490(一种酪氨酸酶抑制剂)对心肌营养素-1(cardiotrophin-1,CT-1)诱导的心肌细胞肥大的影响。方法:利用CT-1刺激心肌细胞造成细胞肥大,同时用AG490进行干预;检测心肌细胞大小、3H-亮氨酸掺入率和β-肌球蛋白重链(β-MHC)mRNA的表达。结果:经CT-1刺激后心肌细胞形态变大(q=16.47,P<0.01),3H-亮氨酸掺入率和β-MHCmRNA表达增加(P<0.01);AG490能抑制CT-1引起的心肌细胞肥大(q=10.37,P<0.01)、3H-亮氨酸掺入率和β-MHCmRNA表达的增高(P<0.01)。结论:AG490能够部分抑制CT-1所诱导的心肌细胞肥大。Objective： To study the effect of AG490 on hypertrophy of cardiomyocytes induced by cardiotrophin- 1 （CT- 1 ）. Methods ： The cultured cardiomyocytes were treated with CT- 1 to induce hypertrophy of cardiomyocytes. The cell size, 3H-leucine incorporation and the mRNA levels of β-MHC were examined. Results： After stimulated by CT-1 the cardiomyocytes were enlarged （q= 16, 47, P〈0.01）. Both 3H-leucine incorporation and the mRNA levels of β-MHC increased （P〈0.01）. AG490 partly inhibited those effects of CT-1 （P〈0.01 all）. Conclusion： CT-1 may induced the cardiomyocytes hypertrophy. AG490 can partly inhibit the cardiomyocytes hypertrophy induced by CT-1.

关 键 词：心肌营养素-1 AG490 心肌 细胞增大 

分 类 号：R542.2[医药卫生—心血管疾病]