锌(Ⅱ)锇(Ⅱ)双卟啉的合成及其与牛血清白蛋白的相互作用  

Synthesis of Zinc(Ⅱ)-Osmium(Ⅱ) Porphyrin Dimer and Its Interaction with Bovine Serum Albumin

作　　者：陈春桥[1] 王星[1] 侯安新[1] 

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《武汉大学学报（理学版）》2006年第4期405-409,共5页Journal of Wuhan University:Natural Science Edition

基　　金：湖北省自然科学基金资助项目(2001ABB055)

摘　　要：在溶剂二乙二醇单甲醚中,以单核锌双卟啉和十二羰基三锇为原料在200℃下回流反应合成了以1,3-二氧丙基相连的锌(Ⅱ)锇(Ⅱ)双卟啉,采用紫外可见光谱(UV-Vis),红外(IR)光谱,核磁共振氢(1H NMR)谱,高分辩质谱(HR-MS)对其结构进行了表征.结果发现锌(Ⅱ)锇(Ⅱ)双卟啉主要处于开放式构象.锌(Ⅱ)锇(Ⅱ)双卟啉与牛血清白蛋白(BSA)的相互作用的荧光光谱分析表明锌(Ⅱ)锇(Ⅱ)双卟啉对BSA的荧光具有较强的猝灭作用.The zinc （ Ⅱ ）-osmium（ Ⅱ ） porphyrin dimer which was linked with flexible propoxy chain was synthesized, using zinc（ Ⅱ ） porphyrin dimer and triosmium dodecarbonyl as reactants while the solvent diethylene glycol monomethyl ether was refluxing at 200℃. This novel compound was identified by UV-Vis, IR, ^1 H NMR and HR-MS. The results indicate that its conformation is mainly unfolded. The interaction of the porphyrin dimer with bovine serum albumin（BSA） in fluorescence spectrum was investigated. The result shows that the product has a strong ability of quench the fluorescence of BSA.

关 键 词：锌(Ⅱ)锇(Ⅱ)双卟啉 合成 表征 构象 牛血清白蛋白 荧光光谱 

分 类 号：O627[理学—有机化学]