血管紧张素转化酶抑制药协助心房颤动复律的维持  

Angiotensin-converting enzyme inhibitors improved the effectiveness of amiodarone on recovering the sinus rhythm in patients with persistent atrial fibrillation

作　　者：贾新未[1] 王晓娜[2] 邸丕凡[1] 李京波[3] 魏盟[3] 

机构地区：[1]河北大学附属医院心内科 [2]保定市妇幼保健院 [3]上海市第六人民医院,上海200233

出　　处：《岭南心血管病杂志》2006年第4期289-291,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的观察血管紧张素转化酶抑制药(angiotensin-convertingenzymeinhibitor,ACEI)能否改善胺碘酮对持续性心房颤动的转律效果。方法持续性心房颤动病人74例,口服胺碘酮0.6g/d,疗程2周。随机分为2组,即ACEI组和非ACEI药组,观察转律成功率和转律成功所需的时间。结果ACEI组胺碘酮转律成功率67.6%(23/34),显著高于非ACEI组(42.5%,17/40)(P<0.05);ACEI组转律平均时间为9.2d,显著少于非ACEI药组11.5d(P<0.01)。结论对持续性心房颤动病人进行胺碘酮转律治疗时,加用ACEI可增加转律成功率,并缩短转律所需时间。Objectives To investigate whether angiotensin-converting enzyme inhibitor （ACEI） can improve the sinus rhythm recovery effect of amiodarone on patients with persistent atrial fibrillation. Methods 74 patients were divided into two groups randomly, that were ACEI group （n=34） and non-ACEI group （n= 40）. All patients in the two groups were given oral arniodarone 0.6 g/day for 2 weeks. The sinus rhythm recovery rate and the time needed were studied. Results The sinus rhythm recovery rate in ACEI group was 67.6% （23/34）, whereas it was 42.5% （17/40） in non-ACEI group （P〈0.05）. The time needed for sinus rhythm recovery was less in ACEI group （9.2 days） than that in non-ACEI group （11.53 days） （P〈0.01）. Conclusions To recover the sinus rhythm for patients with persistent atrial fibrillation, ACEI combined with amiodarone, can raise the success rate and shorten the reverse time needed.

关 键 词：血管紧张素转化酶抑制药 胺碘酮 心房颤动 

分 类 号：R972.3[医药卫生—药品] R541.7[医药卫生—药学]