柴胡清肝汤抗炎作用的实验研究  

Experimental Studyon the Anti-inflammatory Effect of “Chaihu Qinggan Tang”

作　　者：贺玉琢[1] 富杭育[1] 周爱香 郭淑英[1] 沈鸿[1] 查显元[1] 高英杰[1] 姚祥珍[1] 

机构地区：[1]中国中医研究院中药研究所

出　　处：《中国实验方剂学杂志》1996年第5期19-22,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：以柴胡清肝汤５００、１０００、２０００ｍｇ／ｋｇ一次口饲大鼠，在所试剂量范围内，均能显著抑制组织胺、五－羟色胺、前列腺素Ｅ＿２诱发的毛细血管通透性增高，并对肉芽组织增生也有显著的抑制作用。提示柴胡清肝汤不仅对炎症早期的渗出，而且对炎症后期的肉芽组织增生均具功效，对免疫器官司的重量无明显影响。Peroral administration of 500、1000 or 2000 mg/kg of the decoction Chaihu Qing- gan Tang signnificantly inhibited the increment of capillary permeability induced by local injectionof histamine,5-HT or PEG2 on the rat skin and the granulomatous hyperplasia caued by cottonball implantation as well.These findings suggested that both exudation in the early stage andgranulomatous hyperplasia in the late stage of the inflammation were inhibited by the decoction. The efficiency of the decoction was weaker as compared with that of hydrocortisone(10mg/kg).No side-effect on the immune organs was observed.

关 键 词：柴胡清肝汤 抗炎作用 药理学 中药 方剂 

分 类 号：R289.5[医药卫生—方剂学]