不同海拔地区人群触珠蛋白、转铁蛋白指标变化的观察  

Change of Haptoglobin and Transferrin on Healthy People at Different Altitude.

作　　者：周晶苹[1] 彭海[1] 顾松琴[1] 刘兰[1] 王梁[1] 

机构地区：[1]青海省人民医院临床免疫研究室,西宁810007

出　　处：《中华临床医学杂志》2006年第8期17-18,共2页Chinese Journal of Clinical Practical Medicine

摘　　要：目的为观察高海拔地区触珠蛋白（HPT）、转铁蛋白（TRF）的变化，我们对不同海拔：北京（50m）、西宁（2260m）、雁石坪（4750m）地区人群进行了血清HTT、TRF的检测。方法采用散射比浊法，分别对以上3个海拔地区人群的血清标本检测并进行比较。结果HPT从数值上看随海拔增高而下降，分别为0．81±0．41、0．76±0．36、0．73±0．32，但统计学上无差异：TRF随海拔的增高而上升，分别为2．50±0．29、2．66±0．29、3．15±0．40，P〈0．01和P〈0．001。我们还将4750m的高血红蛋白组和血红蛋白在160～179g/L组的HPT、TRF进行比较，HPT分别为0．584±0．35、0．75±0．42，随血红蛋白的增高而降低，P〈0．05：TRF两组间无差异。结论高原地区低氧、低气压造成红细胞代偿性增高，机体由于多种原因引起代谢紊乱，因此检测血清HPT、TRF对高原人群的影响的研究实属必要。Objective We carried out determination in the serum of the haptoglobin（HPT） and transferrin（TRF） of healthy people at Beijing （50m）, Xining（2260m） and Yanshiping（4750m） in order to study the change of the HPT and TRF. Methods Serum concentrations of HPT and TRF were measured by dispersiou-nephelometer assay. Results HPT was decreasing with altitude. They were 0.81 ±0.41. 0.76±0.36 and 0.73 ± 0.32 respectively（P〉0.05）. TRF was enhanced with increasing of the altitude. They were 2.50±0.29, 2.66±0.29 and 3.15±0.40, respectively（P〈0.01and P〈0.001）. We also compared with HPT and TRF between high hemoglobin and normal hemoglobin in 160 to 179g/L groups at 4750m. HPT was 0.58 ±0.35 and 0.75 ±0.42, respectively. It was dropped by increasing of the hemoglobin （P〈0.05）.There was no difference on TRF between high hemoglobin and normal hemoglobin in the two groups. Conclusion Hypoxia and low air pressure at high altitude areas result in increasing of erythrocyfe compensation and metabolism disorders of the body. Therefore it is neccessary to determinate the serum concentrations of the HPT and TRF in order to study their influence on people at high altitude areas.

关 键 词：高原 不同海拔 触珠蛋白 转铁蛋白 血红蛋白 

分 类 号：R446.62[医药卫生—诊断学]